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ChemicalBook Product Catalog Biochemical Engineering Nucleoside drugs Nucleotides and their analogs Nicotinamide N-oxide

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Nicotinamide N-oxide NEW

$33.00 50mg

$48.00 100mg

Min. Order
Purity99.9%
Cas No1986-81-8
Supply Ability10g
Update time2025-04-29

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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Chemical Properties

Product Name	Nicotinamide N-oxide
CAS No	1986-81-8
EC-No
Min. Order
Purity	99.9%
Supply Ability	10g
Release date	2025/04/29

Product Introduction

Bioactivity

Name	Nicotinamide N-oxide
Description	Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.
In vitro	Nicotinamide, a vitamin B3 variant, serves as a precursor to nicotinamide adenine dinucleotide, crucial for oxidative phosphorylation and dehydrogenase cofactor roles. It undergoes metabolism via two pathways: initial methylation by nicotinamide N-methyltransferase, followed by aldehyde oxidase oxidation, and direct oxidation to nicotinamide N-oxide. Studies have introduced a range of nicotinamide N-oxides as innovative, effective CXCR2 receptor antagonists. Specifically, Compound 1 effectively inhibits neutrophil chemotaxis (IC50=10 nM), whereas Compound 2 selectively blocks IL-8 binding (IC50=110 nM) and also significantly hampers neutrophil chemotaxis (IC50=170 nM).
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 3.85 mg/mL (27.85 mM), Sonication is recommended. H2O : Limited solubility
Keywords	Nicotinamide N-oxide \| Nicotinamide Noxide \| Nicotinamide N oxide \| Nicotinamide \| Inhibitor \| inhibit \| EndogenousMetabolite \| Endogenous Metabolite \| DrugMetabolite \| Drug Metabolite \| CXCR \| CXC chemokine receptors \| c-Myc \| cMyc
Inhibitors Related	Sucrose \| Acetaminophen \| Daidzein \| Guanidine hydrochloride \| Fumaric acid \| Ferulic Acid \| L-Methionine \| Formamide \| Glycerol \| Thymidine \| Naringin \| 3-Indoleacetic acid
Related Compound Libraries	Traditional Chinese Medicine Monomer Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Selected Plant-Sourced Compound Library \| Natural Product Library \| Inhibitor Library \| Natural Product Library for HTS \| Bioactive Compounds Library Max \| Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library \| Gut Microbial Metabolite Library \| GPCR Compound Library \| Food as Medicine Compound Library

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