1986-81-8
基本信息
N-氧代烟酰胺
烟酰胺-N-氧化物
烟碱-N-氧化物
3-(AMINOCARBONYL)PYRIDINIUM-1-OLATE
AKOS 94294
NICOTINAMIDE 1-OXIDE
NICOTINAMIDE N-OXIDE
TIMTEC-BB SBB004187
3-Pyridinecarboxamide, 1-oxide
3-Pyridinecarboxamide,1-oxide(9CI)
1-Oxidopyridin-1-ium-3-carboxamide
Nicotinamide-N-oxide ,98%
3-Carbamoylpyridine 1-oxide
3-Pyridinecarbamide 1-oxide
物理化学性质
| 熔点 | 291-293 °C (dec.)(lit.) |
| 沸点 | 253.51°C (rough estimate) |
| 密度 | 1.3471 (rough estimate) |
| 折射率 | 1.5100 (estimate) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于DMSO（略微加热）、甲醇（略微加热） |
| 酸度系数(pKa) | 14.38±0.50(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至灰白色 |
| 敏感性 | 吸湿性 |
| 检测方法 | HPLC,NMR |
| CAS 数据库 | 1986-81-8(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P261-P305+P351+P338-P280a-P304+P340-P405-P501a |
| 危险品标志 | Xi |
| 危险类别码 | R36/37/38 |
| 安全说明 | S26-S36 |
| WGK Germany | 3 |
| 海关编码 | 29339900 |
应用领域
图谱信息
N-氧代烟酰胺(1986-81-8)质谱(MS)N-氧代烟酰胺(1986-81-8)核磁图(1HNMR)N-氧代烟酰胺(1986-81-8)核磁图(13CNMR)N-氧代烟酰胺(1986-81-8)红外图谱(IR1)N-氧代烟酰胺(1986-81-8)红外图谱(IR2)知名试剂公司产品信息
Nicotinamide-N-oxide, 98%(1986-81-8) Acros Organics
Nicotinamide N-Oxide,>98.0%(T)(1986-81-8) TCI Shanghai
N-氧代烟酰胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-101407 | N-氧代烟酰胺 Nicotinamide N-oxide | 1986-81-8 | 100mg | 500元 |
| 2024/01/25 | HY-101407 | N-氧代烟酰胺 Nicotinamide N-oxide | 1986-81-8 | 10mM * 1mLin DMSO | 550元 |
| 2024/01/16 | H61292 | 烟酰胺 N-氧化物, 98% Nicotinamide N-oxide, 98% | 1986-81-8 | 25g | 4077元 |
常见问题列表
|
CXCR2
|
Human Endogenous Metabolite
|
Nicotinamide is one of the forms of vitamin B 3 . It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC 50 =10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC 50 =110 nM) and potent inhibitor of neutrophil chemotaxis (IC 50 =170 nM).