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PICROTOXININ

PICROTOXININ Structure
PICROTOXININ
  • CAS No.17617-45-7
  • Chemical Name:PICROTOXININ
  • CBNumber:CB7420980
  • Molecular Formula:C15H16O6
  • Formula Weight:292.28
  • MOL File:17617-45-7.mol
PICROTOXININ Property
  • Melting point: :203-205°C
  • alpha  :D17 +4.4° (c = 4.28 in abs alc), +3.49° (c = 7.57 in acetone)
  • Boiling point: :354.22°C (rough estimate)
  • Density  :1.2207 (rough estimate)
  • refractive index  :1.4359 (estimate)
  • storage temp.  :2-8°C
  • pka :13.18±0.60(Predicted)
  • form  :neat
  • FDA UNII :9K011NUF0R
  • EPA Substance Registry System :Picrotoxinin (17617-45-7)
Safety
  • Hazard Codes  :T+
  • Risk Statements  :25-28
  • Safety Statements  :13-20-45-36/37-28
  • RIDADR  :3172
  • WGK Germany  :3
  • RTECS  :PC5150000
  • HazardClass  :6.1(a)
  • PackingGroup  :I
  • Toxicity :LD50 i.p. in mice: 3 mg/kg (Jarboe)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300
  • Precautionary statements P264-P301+P310
PICROTOXININ Price More Price(4)
  • Brand: Sigma-Aldrich
  • Product number: Y0001528
  • Product name : Picrotoxinin
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: y0001528
  • Price: $190
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: Y0001528
  • Product name : Picrotoxinin
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: P8390
  • Product name : Picrotoxinin
  • Purity: 
  • Packaging: 250mg
  • Price: $191
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: PHL80339
  • Product name : Picrotoxinin
  • Purity:  phyproof? Reference Substance
  • Packaging: 20mg
  • Price: $173
  • Updated: 2021/03/22
  • Buy: Buy

PICROTOXININ Chemical Properties,Usage,Production

  • Enzyme inhibitor These neurotoxic GABAA receptor antagonists, consisting of a nearly 1:1 mixture of picrotoxinin, (FW = 292.29 g/mol; CAS 17617-45-7) and picrotin (FW = 310.30 g/mol; CAS 124-87-8), is a bitter-tasting (hence the Greek prefix picros) principle, also known as cocculin, from fishberry seeds (Anamirta cocculus) and the Philippine bayating (Tinomiscium philippinense). Picrotoxin binds to the chloride channel of the receptor without displacing g-aminobutyric acid. Picrotoxin is highly toxic, exerting both stimulant and convulsant effects, and care must be exercised when handling this agent.
PICROTOXININ Preparation Products And Raw materials
Raw materials
Preparation Products
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17617-45-7, PICROTOXININRelated Search:
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  • PICROTOXININ
  • Yellowmouth Dutchmanspipe Root
  • Picrotoxinin CRS
  • 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-
  • PICROTOXININ USP/EP/BP
  • 17617-45-7
  • C15H16O6
  • C15H16O6H2O
  • GABAA receptor antagonist; binds to the GABA receptor-linked Cl- channel.
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Ligand-Gated Ion Channels
  • Ion Channels
  • GABA and Glycine Receptor Modulators
  • Miscellaneous Natural Products
  • AntagonistsIon Channels
  • GABA and Glycine Receptor Modulators
  • GABAergics
  • Ligand-Gated Ion Channels
  • Neurotransmitters