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PICROTOXININ

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PICROTOXININ Basic information
PICROTOXININ Chemical Properties
  • Melting point:203-205°C
  • alpha D17 +4.4° (c = 4.28 in abs alc), +3.49° (c = 7.57 in acetone)
  • Boiling point:354.22°C (rough estimate)
  • Density 1.2207 (rough estimate)
  • refractive index 1.4359 (estimate)
  • form neat
  • pka13.18±0.60(Predicted)
  • EPA Substance Registry SystemPicrotoxinin (17617-45-7)
Safety Information
  • Hazard Codes T+
  • Risk Statements 25-28
  • Safety Statements 13-20-45-36/37-28
  • RIDADR 3172
  • WGK Germany 3
  • RTECS PC5150000
  • HazardClass 6.1(a)
  • PackingGroup I
  • ToxicityLD50 i.p. in mice: 3 mg/kg (Jarboe)
PICROTOXININ Usage And Synthesis
  • Enzyme inhibitorThese neurotoxic GABAA receptor antagonists, consisting of a nearly 1:1 mixture of picrotoxinin, (FW = 292.29 g/mol; CAS 17617-45-7) and picrotin (FW = 310.30 g/mol; CAS 124-87-8), is a bitter-tasting (hence the Greek prefix picros) principle, also known as cocculin, from fishberry seeds (Anamirta cocculus) and the Philippine bayating (Tinomiscium philippinense). Picrotoxin binds to the chloride channel of the receptor without displacing g-aminobutyric acid. Picrotoxin is highly toxic, exerting both stimulant and convulsant effects, and care must be exercised when handling this agent.
PICROTOXININ(17617-45-7)Related Product Information
PICROTOXININSupplierMore
  • Company Name:Shanghai Tauto Biotech Co., Ltd
  • Tel:021-51320588
  • Email:tauto@tautobiotech.com
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  • Company Name:ChemStrong Scientific Co.,Ltd
  • Tel:15920483169 0755-66853366-
  • Email:sales@chem-strong.com
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  • Company Name:Wuxi Zhongkun Biochemical Technology Co., Ltd.
  • Tel:18013409632
  • Email:sales@reading-chemicals.com;
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  • Company Name:Sigma-Aldrich
  • Tel:800-8193336 021-61415566-
  • Email:orderCN@merckgroup.com;orderCN@merckgroup.com
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  • Company Name:Shanghai YuanYe Biotechnology Co., Ltd.
  • Tel:18572826883
  • Email:3008007432@qq.com
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