Chemical Properties
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Phosmet

Chemical Properties
Phosmet Structure
Phosmet
  • CAS No.732-11-6
  • Chemical Name:Phosmet
  • CBNumber:CB6681168
  • Molecular Formula:C11H12NO4PS2
  • Formula Weight:317.32
  • MOL File:732-11-6.mol
Phosmet Property
  • Melting point: :72.5°C
  • Boiling point: :412.6±47.0 °C(Predicted)
  • Density  :1.03 g/cm3
  • vapor pressure  :6.5×10-5 Pa (25°C)
  • Flash point: :>100 °C
  • storage temp.  : 0-6°C
  • form  :solid
  • Water Solubility  :25 mg l-1 (25°C)
  • pka :-2.63±0.20(Predicted)
  • BRN  :264869
  • CAS DataBase Reference :732-11-6(CAS DataBase Reference)
  • EWG's Food Scores :2
  • FDA UNII :VN04LI540Y
  • NIST Chemistry Reference :Phosmet(732-11-6)
  • EPA Substance Registry System :Phosmet (732-11-6)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H312-H330-H410
  • Precautionary statements P260-P280-P304+P340+P310-P403+P233
Phosmet Price More Price(4)
  • Brand: Sigma-Aldrich
  • Product number: 36195
  • Product name : Phosmet
  • Purity: PESTANAL
  • Packaging: 100mg
  • Price: $77.6
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 25812
  • Product name : Phosmet
  • Purity: ≥95%
  • Packaging: 25mg
  • Price: $30
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 25812
  • Product name : Phosmet
  • Purity: ≥95%
  • Packaging: 50mg
  • Price: $45
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 25812
  • Product name : Phosmet
  • Purity: ≥95%
  • Packaging: 100mg
  • Price: $60
  • Updated: 2021/03/22
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Phosmet Chemical Properties,Usage,Production

  • Chemical Properties Phosmet is an off-white crystalline solid with an offensive odour.It is very soluble in acetone, xylene, methanol, benzene, toluene, and methyl isobutyl ketone; in kerosene. Phosmet is combustible and susceptible in the presence of strong reducing agents and hydrides. It forms highly toxic and flammable phosphine gas. On partial oxidation by oxidising agents, phosmet releases toxic phosphorus oxides. On heating and/or burning, phosmet decomposes and produces toxic fumes including nitrogen oxides, phosphorous oxides, and sulphur oxides.
  • Chemical Properties Phosmet is a white crystalline solid
  • Uses Nonsystemic acaricide and insecticide used on citrus, fruit, grape and potato crop
  • Uses Phosmet is used to control a wide range of insects and mites in fruit, potatoes, sweet potatoes, vines, cotton and many other crops. It is also used as a veterinary ectoparasiticide.
  • Uses Phosmet is used as a pesticide to protect crops and vegetation. Insecticide.
  • Uses Insecticide, acaricide.
  • General Description Off-white crystalline solid with an offensive odor. Used as an insecticide and acaricide.
  • Reactivity Profile Organophosphates, such as Phosmet, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Storage above 113 F, may lead to decomposition. [EPA, 1998].
  • Health Hazard Phosmet is an organophosphorus pesticide. Phosmet is very toxic; the probable oral lethal dose for humans is 50-500 mg/kg, or between 1 teaspoon and 1 oz. for a 150 lb. person. It is a cholinesterase inhibitor and has central nervous system effects. Oral lethal doses in humans have been reported at 50 mg/kg.
  • Fire Hazard (Non-Specific -- Organophosphorus Pesticide, n.o.s.). Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Storage above 113F, may lead to decomposition.
  • Agricultural Uses Insecticide, Acaricide: Phosmet is a non-systemic insecticide used on both plants and animals. It is mainly used on apple trees for control of coddling moth, though it is also used on a wide range of crops including alfalfa, nuts, grapes, blueberries, peas, potatoes, fruit crops, ornamentals, and vines for the control of aphids, suckers, mites, fire ants and fruit flies. The compound is also an active ingredient in some dog collars. It is used as an insecticide on swine and cattle. U.S. Maximum Allowable Residue Levels for Phosmet [40 CFR 180.261 (a)]: Alfalfa 40 ppm; almond, hulls 10 ppm; apple 10 ppm; apricot 5 ppm; blueberry 10 ppm; cattle, fat 0.2 ppm; cattle, meat 0.2 ppm; cattle, meat byproducts 0.2 ppm; cherry 10 ppm; cotton, undelinted seed 0.1 ppm; crabapple 20 ppm; cranberry 10 ppm; fruit, stone, group 12 5 ppm; goat, fat 0.2 ppm; goat, meat0.2 ppm; goat, meat byproducts 0.2 ppm; grape 10 ppm; hog, fat 0.2 ppm; hog, meat 0.2 ppm; hog, meat byproducts 0.2 ppm; horse, fat 0.2 ppm; horse, meat 0.2 ppm; horse, meat byproducts 0.2 ppm; kiwifruit 25 ppm; nectarine 5 ppm; nuts 0.1 ppm; pea 0.5 ppm; pea, field, hay 10 ppm; pea, field, vines 10 ppm; peach 10 ppm; pear 10 ppm; pistachio 0.1 ppm; plum, prune, fresh 5 ppm; potato 0.1 ppm; sheep, fat 0.2 ppm; sheep, meat 0.2 ppm; sheep, meat byproducts 0.2 ppm; sweet potato, roots 10 ppm. Regional registration, as defined in section 180.1(n) [40 CFR 180.261 (c)]: Crabapple 20 ppm; pistachio 0.1 ppm.
  • Trade name Trade Names: APPA®; DECEMTHION®; DELPHOS ®; FESDAN®; FIREBAN®; FTALOPHOS®; IMIDAN®; KEMOLATE®; PERCOLATE®; PMC®; PROLATE®[C]; R 1504®; SAFIDON®; SMIDAN®; STARBAR CATTLE DUST®[C]; STAUFFER R 1504®; VET-KEM®; ZEOCON®
  • Safety Profile A human poison by ingestion. Poison experimentally by inhalation and ingestion routes. Moderately toxic by skin contact. Human systemic effects by inhalation: lachqmation, somnolence, and olfaction effects. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx. See also ESTERS.
  • Potential Exposure An organophosphorus insecticide and acaricide.
  • Carcinogenicity No treatment-related increases in tumor incidence occurred in rats given a diet with 0, 20, 40,200, or 400 ppm (400 ppm terminated at 12 months) (equivalent to 0, 1.1, 1.8, 9.4, and 23 mg/kg/day in males and 0, 1.1, 2.1, 10.9, and 27 mg/kg/day in females) for 2 years .
    When mice were given diets with 0, 5, 25, or 100 ppm phosmet (approximately 0.75, 3.75, or 15.0 mg/kg/day) for 2 years, there was an increased incidence of hepatocellular tumors in males and mammary gland tumors in females .
  • Environmental Fate Soil. In soils, phosmet is rapidly hydrolyzed to phthalimide (Camazano and Martin, 1980; Sánchez Camazano and Sánchez Martin, 1983). The rate of hydrolysis is greater in the presence of various montmorillonite clays and chloride salts. The calculated hydrolysis half-lives of phosmet in the presence of calcium, barium, copper, magnesium and nickel montmorillonite clays were 0.084, 0.665, 10.025, 16.926 and 28.738 days, respectively. Similarly, the half-lives of phosmet in the presence of copper, calcium, magnesium and barium chlorides were <0.020, 5.731, 10.680 and 12.242 days, respectively. In comparison, the hydrolysis of phosmet in a neutral water solution was 46.210 days (Sánchez Camazano and Sánchez Martin, 1983)
    Plant. In plants, phosmet is degraded to nontoxic compounds (Hartley and Kidd, 1987). Dorough et al. (1966) reported the half-life in Bermuda grass was 6.5 days. Half-life values ranged from 1.2 to 6.5 days (Dorough et al., 1966; Leuck and Bowman
    Chemical/Physical. Emits toxic fumes of phosphorus, nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987). Though no products were identified, the
    hydrolysis half-lives at 20°C were 7.0 days and 7.1 hours at pH 6.1 and pH 7.4, respectively. At 37.5°C and pH 7.4, the hydrolysis is 1.1 hours (Freed et al., 1979)
  • Metabolic pathway The main degradative route of phosmet metabolism in plants and animals is similar with the compound being hydrolysed via attack on the carbonyl group of the phthaloyl moiety, yielding phthalamic acid which is further hydrolysed and decarboxylated to benzoic acid. It should be noted, however, that the studies on which the evidence for these metabolites is based are old and used paper chromatography for the main analytical evidence. A rather later study in rats identified N-hydroxymethylphthalimide and phthalimide as metabolites, implying a degradative hydrolytic route via attack on the N-methylene carbon atom. Oxidative desulfuration to the active acetylcholinesterase inhibitor phosmet oxon predominates over hydrolysis in insects and is responsible for the selectivity of the compound.
  • Metabolism Orally administered phosmet in mammals is rapidly degraded to phthalamic acid, phthalic acid, and phthalic acid derivatives, and the metabolites are excreted in the urine. Oxidative desulfuration to the oxon predominates over hydrolysis in insects. It is rapidly degraded in plants and soils.
  • Shipping UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1Poisonous materials, Technical Name Required.
  • Degradation Phosmet is relatively stable in acid media but it is hydrolysed under basic conditions. The half-lives at pH values 4.5, 7 and 8.3 were 13 days, <12 hours and <4 hours, respectively (PM). Phosmet was hydrolysed under basic conditions to phthalamic acid (2), phthalic acid (3) and O,Odimethyl phosphorodithioate (4) indicating that nucleophic attack by OH-occurs preferentially on the phthalimido carbonyl group rather than on phosphorus (Menn et al., 1965) (Scheme 1). The photolysis of an ether solution of phosmet irradiated in a quartz tube by unfiltered UV light from a mercury vapour lamp was investigated by Tanabe ef al. (1974). Photoproducts were separated by silica gel column chromatography and characterised by GLC, TLC, MS and 1H NMR spectroscopy in comparison with authenticated reference standards. Two major photoproducts were identified as N-methylphthalimide (5) and N-methoxymethylphthalimide (6) (Scheme 1) in addition to a large number of minor products which were not characterised. The use of a Pyrex filter to remove light below 286 nm reduced the rate of photolysis but not the nature of the products. N-Methoxymethylphthalimide (6) was the main product when phosmet was irradiated by sunlight in thin films on silica gel TLC plates or in dilute aqueous solution [personal communication by McBain and Menn (1973), in Tanabe et al., 1974].
  • Toxicity evaluation The acute oral LD50 for rats is 113–160 mg/kg. Inhalation LC50 (1 h) for rats is 2.76 mg/L air. NOEL (2 yr) for rats is 40 mg/kg/d. ADI is 0.01 mg/kg bw.
  • Incompatibilities Organothiophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrideds and active metals. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Not compatible with other pesticides under alkaline conditions. Contact with water, steam or moisture forms phthalic acids. Slightly corrosive to metals in the presence of moisture.
  • Waste Disposal Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Small amounts may be decomposed with hypochlorite. For large amounts, incineration with effective gas scrubbing is recommended.
Phosmet Preparation Products And Raw materials
Raw materials
Preparation Products
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