Uses
2,4-Dimethoxybenzylamine is an amine nucleophile used to investigate the 1,4- reactivity of 5-bromo-2-indene-1-one. It may be used in the following studies:
- As an ammonia equivalent in the concise synthesis of a series of 2,4,5-trisubstituted oxazoles, via a tandem Ugi/Robinson-Gabriel reaction sequence.
- Total synthesis of (-)-muraymycin (MRY) D2 and its epimer, the antibacterial nucleoside natural product.
- Two-step synthesis of amide derivatives of uracil polyoxin C (UPOC) methyl ester using the Ugi reaction.
- Synthesis of N-hydroxythiourea.
- Synthesis of anti-HIV-1 agents.
General Description
2,4-Dimethoxybenzylamine can be preprepared by reduction (NaBH
4 , BF
3.OEt
2, THF) of 2,4-dimethoxybenzonitrile.
