Chemical Properties
White or almost white, crystalline powder or colourless crystals, hygroscopic.
Uses
Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.
Uses
topical fluoroquinolone antibiotic for acne
Biological Activity
Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.
Safety Profile
Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.
in vivo
Noscapine (300?mg/kg; oral gavage; daily; for 15 days; athymic female mice) hydrochloride treatment reduces tumor growth in mice[1].
| Animal Model: | Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells[1] |
| Dosage: | 300?mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Revealed a significant reduction of tumor volume.
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