Uses
p-Toluenesulfonyl Hydrazide is a reactant that has been used in the synthesis of paspaline.
Chemical Properties
white to off-white powder
Uses
4-Methylbenzenesulfonhydrazide was widely used reagent for the preparation of tosylhydrazones.
Application
p-Toluenesulfonyl hydrazide is used as a reagent for the preparation of tosylhydrazones. It was used to prepare dipyrazolo[1,5-a:4',3'-c]pyridines and 1,2,3-selenadiazole derivatives.
Reactions
4-Methylbenzenesulfonhydrazide as hydrogen donor in reduction reactions:
A base-mediated semihydrogenation of ynamides using 4-Methylbenzenesulfonhydrazide (p-toluenesulfonyl
hydrazide) as an inexpensive and easy-to-handle hydrogen donor provides the
thermodynamically unfavorable Z-enamides exclusively without
overhydrogenation and reduction of other functional groups.
Flammability and Explosibility
Not classified
Purification Methods
Dissolve the 4-Methylbenzenesulfonhydrazide in hot MeOH (~1g/4mL), filter through Celite and precipitate the material by adding 2-2.5 volumes of distilled H2O. Dry it in air or in a vacuum. [Fiedman et al. Org Synth Coll Vol V 1055 1973, Beilstein 11 II 66.]
