Description
Tosyl azide is a reagent used in organic synthesis. It is prepared by the reaction of tosyl chloride with sodium azide in aqueous acetone.
Applications
Tosyl azide is utilized for the introduction of diazo and azide functional groups. Moreover, it is used as a nitrene and a substrate for [3+2] cycloaddition reactions.
Safety
Tosyl azide is a very volatile chemical that should be carefully stored and handled.
Chemical Properties
Colorless to slight yellow liquid
Uses
p-Toluenesulfonyl azide solution can be employed as a reagent along with alkyne, and amine in the three-component coupling reaction for the synthesis of
N-sulfonylamidines in presence of copper catalyst.
It can also be used in the synthesis of
N-sulfonyl-1,2,3-triazoles by azide-alkyne cycloaddition reaction in the presence of copper catalyst.
Uses
Used for the introduction of azide and diazo functional groups. It is also used as a nitrene source and as a substrate for [3+2] cycloaddition reactions.
Uses
4-Methylbenzenesulfonyl Azide can be used to target Bcl-2 family proteins to potentially treat cancer.
