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p-Anisidine

p-Anisidine Structure
p-Anisidine
  • CAS No.104-94-9
  • Chemical Name:p-Anisidine
  • CBNumber:CB6852649
  • Molecular Formula:C7H9NO
  • Formula Weight:123.15
  • MOL File:104-94-9.mol
p-Anisidine Property
  • Melting point: :56-59 °C(lit.)
  • Boiling point: :240-243 °C(lit.)
  • Density  :1.06
  • vapor density  :4.28
  • vapor pressure  :0.02 hPa (20 °C)
  • refractive index  :1.5559
  • Flash point: :122 °C
  • storage temp.  :Store below +30°C.
  • solubility  :21g/l
  • pka :5.34(at 25℃)
  • form  :crystalline
  • color  :dark gray to brown
  • Specific Gravity :1.07
  • PH :7.7 (1g/l, H2O, 20℃)
  • Water Solubility  :21 g/L (20 ºC)
  • Merck  :14,667
  • BRN  :471556
  • Henry's Law Constant :(x 10-8 atm?m3/mol): 6.62 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
  • Exposure limits :NIOSH REL: TWA 0.5 mg/m3, IDLH 50 mg/m3; OSHA PEL: TWA 0.5 mg/m3; ACGIH TLV: TWA 0.1 ppm (adopted).
  • CAS DataBase Reference :104-94-9(CAS DataBase Reference)
  • EWG's Food Scores :2-3
  • FDA UNII :575917SNR4
  • IARC :3 (Vol. 27, Sup 7) 1987
  • NIST Chemistry Reference :Benzenamine, 4-methoxy-(104-94-9)
  • EPA Substance Registry System :p-Anisidine (104-94-9)
Safety
  • Hazard Codes  :T+,N,Xi
  • Risk Statements  :45-26/27/28-33-50
  • Safety Statements  :53-28-36/37-45-61-28A
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :2
  • RTECS  :BZ5450000
  • F  :8
  • Autoignition Temperature :959 °F
  • TSCA  :Yes
  • HazardClass  :6.1
  • PackingGroup  :III
  • HS Code  :29222200
  • Hazardous Substances Data :104-94-9(Hazardous Substances Data)
  • Toxicity :Acute oral LD50 for rats 1,400 mg/kg, mice 810 mg/kg, rabbits 2,900 mg/kg (quoted, RTECS, 1985).
  • NFPA 704:
    1
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300-H301+H311+H331-H315-H319-H370-H372-H412-H301-H310-H330-H350-H373-H400
  • Precautionary statements P301+P310a-P304+P340-P320-P330-P501a-P264-P270-P271-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P307+P311-P391-P403+P233-P405-P501-P201-P260-P273-P280-P284-P301+P310
p-Anisidine Price More Price(16)
  • Brand: Sigma-Aldrich
  • Product number: 8.00458
  • Product name : p-Anisidine
  • Purity: for synthesis
  • Packaging: 100 g
  • Price: $27.47
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: A88255
  • Product name : p-Anisidine
  • Purity: ≥99%
  • Packaging: 5g
  • Price: $18.2
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 8.00458
  • Product name : p-Anisidine
  • Purity: for synthesis
  • Packaging: 500 g
  • Price: $70.85
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: A88255
  • Product name : p-Anisidine
  • Purity: ≥99%
  • Packaging: 1kg
  • Price: $128
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: A0487
  • Product name : p-Anisidine
  • Purity: >98.0%(GC)(T)
  • Packaging: 25g
  • Price: $27
  • Updated: 2021/03/22
  • Buy: Buy

p-Anisidine Chemical Properties,Usage,Production

  • Chemical Properties Anisidine exists as ortho-, meta-, and paraisomers. They have characteristic amine (fishy) odors.
  • Chemical Properties grey to brown crystalline powder, granules
  • Physical properties Yellow to light brown powder, leaflets, solid or crystals with a characteristic amine or ammonialike odor
  • Uses p-Anisidine is used mostly for producing dyes, and some smaller quantities are employed in making pharmaceuticals and liquid crystals.
  • Uses In the preparation of azo dyes; corrosion inhibitor; chemical intermediate
  • Uses p-Anisidine is used as a reagent to indicate the secondary stage of the oxidation, it is one of the three possible isomers of the Anisidine or methoxyaniline. The other two isomers are o-Anisidine (2-methoxyaniline) and m-Anisidine (3-methoxyaniline).
    The p-anisidine is widely used as an intermediate in the production of numerous azo and triphenylmethane dyes, and pigments. It is also used in the production of pharmaceuticals including the guaiacol expectorant, as an antioxidant for polymercaptan resins, and as a corrosion inhibitor for steel. Apart from the beneficial use of p-anisidine, it is toxic for human beings. The acute exposure may cause skin irritation, whereas the chronic exposure may cause headaches, vertigo, and blood complications like sulfhemoglobin, and methemoglobin. The oral exposure to anisidine hydrochloride resulted in cancer of the urinary bladder in male and female rats.
    https://www.longdom.org/open-access/physicochemical-and-spectroscopic-characterization-of-biofield-energytreated-panisidine-paco-1000102.pdf
  • Synthesis Reference(s) Journal of the American Chemical Society, 99, p. 98, 1977 DOI: 10.1021/ja00443a018
    The Journal of Organic Chemistry, 49, p. 1434, 1984 DOI: 10.1021/jo00182a023
    Tetrahedron Letters, 21, p. 2603, 1980 DOI: 10.1016/S0040-4039(00)92816-8
  • General Description Brown crystals or dark brown solid. Characteristic amine odor.
  • Air & Water Reactions Insoluble in water.
  • Reactivity Profile p-Anisidine may be sensitive to heat, light and moisture. Reacts with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. Incompatible with alkaline materials. Incompatible with aldehydes, ketones and nitrates.
  • Hazard Strong irritant. Toxic when absorbed through the skin. Questionable carcinogen.
  • Fire Hazard p-Anisidine is flammable.
  • Safety Profile Moderately toxic by several routes. A mild sensitizer. May cause a contact dermatitis. Mutation data reported. Questionable carcinogen. See also ANILINE. When heated to decomposition it emits toxic fumes of Nox
  • Potential Exposure Anisidines are used in the manufacture of azo dyes; pharmaceuticals; textile-processing chemicals Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some coatings and some forms of plastic and rubber.
  • Carcinogenicity Available data were inadequate to evaluate the carcinogenicity of p-anisidine.
  • Environmental Fate Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).
  • Shipping UN2431 Anisidines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
  • Purification Methods Crystallise p-anisidine from H2O or aqueous EtOH. Dry it in a vacuum oven at 35o for 6hours and store it in a dry box. [More et al. J Am Chem Soc 108 2257 1986.] Purify it also by vacuum sublimation [Guarr et al. J Am Chem Soc 107 5104 1985]. [Beilstein 13 IV 1015.]
  • Waste Disposal Dissolve in combustible solvent (alcohols, benzene, etc.) and spray solution into furnace equipped with afterburner and scrubber, or burn spill residue on sand and soda ash absorbent in a furnace.
p-Anisidine Preparation Products And Raw materials
Raw materials
Preparation Products
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