Chemical Properties
Dark red to brown solid
Uses
5-Methoxyisatin is used for Pharmaceutical intermediates, a raw material used in chemical synthesis.
Preparation
Using water as solvent, 5-methoxyaniline reacted with chloral hydrate and hydroxylamine hydrochloride at 90 ℃ for 3.5h to obtain p-methoxyisonitrosoacetanilide in 95% yield. After hydrolysis, 5-methoxyisatin was obtained in 88% yield by cyclization at 92℃ with concentrated H2SO4 (75%).
Definition
ChEBI: 5-Methoxyisatin is a member of indoles. It has a role as an anticoronaviral agent.
Synthesis Reference(s)
The Journal of Organic Chemistry, 42, p. 1344, 1977
DOI: 10.1021/jo00428a016
