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Amoxapine

Amoxapine Structure
Amoxapine
  • CAS No.14028-44-5
  • Chemical Name:Amoxapine
  • CBNumber:CB5375947
  • Molecular Formula:C17H16ClN3O
  • Formula Weight:313.78
  • MOL File:14028-44-5.mol
Amoxapine Property
  • Melting point: :175-1760C
  • Boiling point: :469.9±55.0 °C(Predicted)
  • Density  :1.2613 (rough estimate)
  • refractive index  :1.5800 (estimate)
  • Flash point: :9℃
  • storage temp.  :Keep in dark place,Inert atmosphere,Room temperature
  • solubility  :methanol: soluble
  • pka :pKa 7.6 (Uncertain)
  • color  :Crystals from benzene/pet ether
  • Merck  :14,576
  • CAS DataBase Reference :14028-44-5(CAS DataBase Reference)
  • FDA UNII :R63VQ857OT
  • Proposition 65 List :Amoxapine
  • ATC code :N06AA17
  • NIST Chemistry Reference :Amoxapine(14028-44-5)
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • Safety Statements  :36
  • RIDADR  :3249
  • WGK Germany  :3
  • RTECS  :HQ4025500
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :2934990002
  • Toxicity :LD50 in mice (mg/kg): 122 i.p.; 112 orally (Howell, 1972)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H341-H225-H301+H311+H331-H370-H302
  • Precautionary statements P201-P202-P264-P270-P307+P311-P405-P501-P301+P312a-P330-P501a-P210-P260-P280-P301+P310+P330-P308+P311-P403+P233-P301+P312+P330
Amoxapine Price More Price(16)
  • Brand: Sigma-Aldrich
  • Product number: A-123
  • Product name : Amoxapine
  • Purity: 1.0?mg/mL in methanol, certified reference material, Cerilliant?
  • Packaging: 1 mL
  • Price: $60.7
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1031401
  • Product name : Amoxapine
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 200mg
  • Price: $366
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: A129
  • Product name : Amoxapine
  • Purity: 
  • Packaging: 5g
  • Price: $790
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: A2499
  • Product name : Amoxapine
  • Purity: >97.0%(GC)(T)
  • Packaging: 1g
  • Price: $120
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: A2499
  • Product name : Amoxapine
  • Purity: >97.0%(GC)(T)
  • Packaging: 5g
  • Price: $423
  • Updated: 2021/03/22
  • Buy: Buy

Amoxapine Chemical Properties,Usage,Production

  • Chemical Properties Crystalline Solid
  • Originator Asendin,Lederle,US,1980
  • Uses Amoxapine is intended more for relieving symptoms in patients with neurotic or situational depression. It has a number of serious side effects.
  • Uses antidepressant, inhibits norepinephrine uptake
  • Definition ChEBI: A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.
  • Manufacturing Process A mixture of 125 g of o-(p-chlorophenoxy)aniline hydrochloride and 100 ml of dry pyridine is treated cautiously with a solution of 90 ml of ethyl chlorocarbonate in 150 ml of ether. The mixture is kept at room temperature for 3 days, diluted with about 500 ml of water and extracted with 300 ml of ether, The ethereal extract is washed with 300 ml of water, dried over calcium chloride, filtered and concentrated. The resulting ethyl o-(pchlorophenoxy) carbanilate is obtained in a viscous oil suitable for use in the next step without further purification.
    A solution of 70 g of ethyl o-(p-chlorophenoxy)carbanilate and 120 g of Ncarbethoxypiperazine in 100 ml of benzene containing a little sodium methoxide is heated on a steam bath for about 5 days. The solvent is removed by distillation and the residue is triturated with water. The resulting solid is dissolved in ether and dried over sodium sulfate. Filtration and concentration then yields ethyl 4-[[o-(p-chlorophenoxy)phenyl]carbamoyl]-1- piperazinecarboxylate, melting at 89°C to 91°C, and suitable for cyclization.
    A mixture of 10 g of the above piperazine carboxylate ester, 8 g of phosphorus pentoxide and 20 ml of phosphorus oxychloride is heated under reflux for about 1 day, diluted with 100 ml each of chloroform and benzene and quenched with 200 g of ice. The mixture is made basic with 10% sodium hydroxide. The organic layer is isolated and extracted with 150 ml of dilute hydrochloric acid. The product is precipitated from the aqueous layer by addition of 10% sodium hydroxide, extracted with benzene and dried over potassium carbonate. Recrystallization from benzene-petroleum ether gives 2- chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine which melts at 175°C to 176°C.
  • brand name Asendin (Lederle).
  • Therapeutic Function Antidepressant
  • General Description Consideration of the structure of amoxapine, 2-chloro-11-(1-piperazinyl)dibenz-[b,f] [1,4]oxazepine (Asendin), reinforcesthe fact that many antidepressants are very closelyrelated to antipsychotics. Indeed, some, including amoxapine,have significant effects at D2 receptors. The Nmethyl–substituted relative of amoxapine is the antipsychoticloxapine (Loxitane). The 8-hydroxy metabolite ofamoxapine is reportedly active as an antidepressant and asa D2 receptor blocker.
  • Mechanism of action Additionally, it is the N-desmethyl metabolite of the antipsychotic loxapine. Amoxapine differs structurally from the other secondary TCAs in that it has both a nitrogen and an oxygen atom in its 7-membered central ring and a piperazinyl ring rather than a propylamino side chain attached to the central ring.Amoxapine is a less potent inhibitor of neuronal NE reuptake compared with the other secondary TCAs, with a mechanism of action similar to that of desipramine.
  • Pharmacokinetics Amoxapine shares the toxic potentials of the TCAs, and the usual precautions of TCA administration should be observed. Amoxapine resembles the atypical antipsychotic drugs in its intermediate affinity as an antagonist of dopamine-2 and of 5-HT2 receptors. Amoxapine is rapidly and almost completely absorbed from the gastrointestinal (GI) tract. Amoxapine and its 8-hydroxyamoxapine metabolite have been detected in human milk at concentrations below steady-state therapeutic concentrations.
  • Pharmacology The antidepressant action of amoxapine is comparable to that of imipramine and amitriptyline. It exhibits antagonistic activity on dopamine (D2) receptors.
  • Clinical Use Amoxapine is a dibenzoxazepine TCA with antidepressant and antipsychotic effects that has shown therapeutic effectiveness in patients with delusional depression.
  • Safety Profile Poison by ingestion andintraperitoneal routes. Human systemic effects byingestion: acute renal failure, acute tubular necrosis, BPlowering, coma, convulsions, decreased body temperature,EKG changes, excitement, fasciculations, heart ratechanges, hype
  • Chemical Synthesis Amoxapine, 2-chloro-11-(1-piperazinyl)-dibenz[b,f]oxazepine (7.3.2), is a direct analog of the neuroleptic loxapine (6.5.3), differing only in the absence of a methyl group in the piperazine region of the molecule. On the other hand, it could be included in the class of tricyclic antidepressants, the main difference being the presence of a side chain on the central 7-membered ring of the tricyclic system. Amoxapine, like loxapine, is synthesized from 2-(4-chlorobenzoxy)aniline, which as in loxapine synthesis is acidified with chlorocarbonic acid into (6.5.1) and further transformed into ureide (7.3.1) upon reaction with 1-carboethoxypiperazine. Cyclization by a mixture of phosphorous pentoxide and phosphorous oxychloride into the dibenzoxazepine and subsequent alkaline hydrolysis gives amoxapine (7.3.2) [50–53].

  • Metabolism Amoxapine has the shortest elimination time (~8 hours) of the secondary TCAs. It is metabolized in the liver principally to 8-hydroxyamoxapine and to 7-hydroxyamoxapine. Both of these metabolites are pharmacologically active and have half-lives of 30 and 6.5 hours, respectively. The hydroxylation of amoxapine is inhibited by ketoconazole, suggesting the involvement of CYP3A4."
Amoxapine Preparation Products And Raw materials
Raw materials
Preparation Products
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  • Amoxapine &gt
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  • 14028-44-5
  • C17H16ClN3O
  • ASENDIN
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