Important pharmaceutical intermediates Pharmacology and mechanism of action Indications Side effects Contraindications and precautions Interactions Preparations Acute oral toxicity Data Skin irritation References Flammability and hazardous characteristics Storage characteristics Extinguishing agent Professional standards
ChemicalBook > CAS DataBase List > Piperazine

Piperazine

Important pharmaceutical intermediates Pharmacology and mechanism of action Indications Side effects Contraindications and precautions Interactions Preparations Acute oral toxicity Data Skin irritation References Flammability and hazardous characteristics Storage characteristics Extinguishing agent Professional standards
Piperazine Structure
Piperazine
  • CAS No.110-85-0
  • Chemical Name:Piperazine
  • CBNumber:CB5852824
  • Molecular Formula:C4H10N2
  • Formula Weight:86.14
  • MOL File:110-85-0.mol
Piperazine Property
  • Melting point: :109-112 °C(lit.)
  • Boiling point: :146 °C
  • Density  :1,1 g/cm3
  • vapor pressure  :0.8 mm Hg ( 20 °C)
  • refractive index  :1.4460
  • FEMA  :4250 | PIPERAZINE
  • Flash point: :65 °C
  • storage temp.  :Store in dark!
  • solubility  :H2O: 0.1 M at 20 °C, clear, colorless
  • pka :9.83(at 23℃)
  • form  :Crystalline Flakes
  • color  :White to slightly yellow
  • PH :11.0-12.5 (25℃, 0.1M in H2O)
  • explosive limit :14%
  • Water Solubility  :150 g/L (20 ºC)
  • λmax :λ: 260 nm Amax: 0.035
    λ: 280 nm Amax: 0.010
  • Sensitive  :Air Sensitive & Hygroscopic
  • JECFA Number :1615
  • Merck  :14,7464
  • BRN  :102555
  • Stability: :Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
  • InChIKey :GLUUGHFHXGJENI-UHFFFAOYSA-N
  • CAS DataBase Reference :110-85-0(CAS DataBase Reference)
  • FDA 21 CFR :556.513; 175.105
  • Substances Added to Food (formerly EAFUS) :PIPERAZINE
  • EWG's Food Scores :2-3
  • FDA UNII :1RTM4PAL0V
  • NIST Chemistry Reference :Piperazine(110-85-0)
  • EPA Substance Registry System :Piperazine (110-85-0)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H361-H314-H317-H334-H361fd
  • Precautionary statements P261-P280-P305+P351+P338-P310-P260-P284-P303+P361+P353-P304+P340+P310-P260h-P405-P501a
Piperazine Price More Price(26)
  • Brand: Sigma-Aldrich
  • Product number: 80621
  • Product name : Piperazine
  • Purity: BioUltra, anhydrous, ≥99.0% (T)
  • Packaging: 25g
  • Price: $66.1
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1541601
  • Product name : Piperazine
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 200mg
  • Price: $338.1
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: P0446
  • Product name : Piperazine Anhydrous
  • Purity: >98.0%(GC)(T)
  • Packaging: 25g
  • Price: $14
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: P0446
  • Product name : Piperazine Anhydrous
  • Purity: >98.0%(GC)(T)
  • Packaging: 500g
  • Price: $34
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: A15049
  • Product name : Piperazine, anhydrous, 99%
  • Purity: 
  • Packaging: 100g
  • Price: $26.2
  • Updated: 2020/06/24
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Piperazine Chemical Properties,Usage,Production

  • Important pharmaceutical intermediates Piperazine is an important pharmaceutical intermediate, is mainly used for the production of anthelmintic piperazine phosphate, piperazine citrate and fluphenazine, strong pain, rifampicin, adipic acid piperazine, piperazine guanidine methyl tetracycline, quinoline piperazine phosphate, piperazine thiazole nitrate, enoxacin, hydroxyzine hydrochloride, trifluoperazine, diethylcarbamazine citrate, cinnarizine, flunarizine, decloxizine strong carbamazepine, prednisolone sodium phosphate, dexamethasone sodium phosphate, PPA, norfloxacin, ciprofloxacin, easy to cough piperazine, a piperazine Lee vancomycin, trimethoprim-triazine and other drugs. It is Also used for the production of surfactants products such as wetting agents, emulsifying agents,and dispersing agents ,and the production of plastic additives such as antioxidants, preservatives, stabilizers and rubber additives. It is derived from Dichloroethane by alcohol solution of ammonia.
    The structural formula of piperazine
    Figure 1 The structural formula of piperazine.
  • Pharmacology and mechanism of action Piperazine is a heterocyclic organic base widely used as an anthelminthic. It was originally developed for the treatment of gout. Its first successful use in helminthiasis was reported by Mouriquand et al. in 1951 [1]. Presently the drug is used in the treatment of infections caused by Ascaris lumbricoides and Enterobius vermicularis.
    The drug causes flaccid paralysis in susceptible worms and the parasites lose their attachment to the intestinal wall, and are swept away by the normal bowel peristalsis. The biochemical mechanism behind this action is uncertain. Piperazine causes hyperpolarization of the Ascaris muscle rendering it unresponsive to acetylcholine [2].
  • Indications Treatment of infections due to Ascaris lumbricoides and Enterobius vermicularis. When cost and availability are not a consideration, safer and more effective drugs such as mebendazole or albendazole should be used instead.
  • Side effects Side effects commonly encountered with the recommended doses of piperazine are nausea, vomiting, abdominal cramps and diarrhoea which are usually mild and self-limiting. Although absolute incidence is unknown, severe side effects reported in the literature are rare. They can be classified into:
    1. Allergic reactions such as urticaria, exantema, hypersensitivity, lacrimation, rhinorrea, productive cough, and bronchospasm[3,4].
    2. Neuro-psychological reactions[5-11]:
    (a) cerebral type such as vertigo, dizziness, tremor, incoordination, ataxia and hypotonia with EEG changes;
    (b) psychic type such as depersonalization, hallucination and paranoic reactions;
    (c) miscellaneous such as headache, visual disturbances, somnolence, coma and an increase in the number of petit mal attacks.
    Neuro-psychological reactions are rare. Most cases reported concern children with pre disposing factors like neurological symptoms, renal diseases or those who have been treated with high doses of piperazine.
    One case of haemolytic anaemia in a patient with G6PD deficiency [12], and one case of toxic hepatitis[13] have also been reported. However, no causal relationships can be established from these cases.
    Nitrosation of piperazine to the potential carcinogen N-mononitrosopiperazine in the stomach of patients treated with normal therapeutic doses has been reported[14]. However, carcinogenicity related to the use of piperazine has not been reported despite the use of the drug over many years. In any case, this is unlikely to have any clinical implications with the short treatment period of nematodes.
  • Contraindications and precautions Piperazine should not be given to patients with hypersensitivity or with neurological diseases,especially epileptic patients.
  • Interactions In rats and mice, piperazine 1–5 g/kg subcutaneously, potentiates the side effects of chlorpromazine [15]. However, this is unlikely to have any clinical significance. Piperazine is antagonistic to pyrantel, bephenium and levamisole , but no potential clinical interactions have been reported.
  • Preparations Several preparations, apart from the one mentioned below, containing various piperazine salts are available.
    • Antepar® (Wellcome). Oral suspension 150 mg piperazine hexahydrate/ml. Tablets 500 mg piperazine hexahydrate.
  • Acute oral toxicity rat LD50: 1900 mg/kg; Oral-Mouse LD50: 600 mg/kg
  • Data Skin irritation rabbit 500 mg Mild; Eyes-rabbit 0.25 mg/24 hours of severe
  • References 1. Mouriquand G, Roman E, Coisnard J (1951). Essai de traitement de l’oxyurose par la piperazine. J Méd Lyon, 32, 189–195.
    2. del Castillo J, De Mello WC, Morales T (1964). Mechanism of the paralysing action of piperazine on Ascaris muscle. Br J Pharmacol, 22, 463–477.
    3. Macmillan AL (1973). Generalized pustular drug rash. Dermatologia, 146, 285–291.
    4. McCullagh SF (1968). Allergenicity of piperazine: a study in environmental aetiology. Br J Ind Med, 25, 319–325.
    5. Belloni C, Rizzoni G (1967). Neurotoxic side-effects of piperazine. Lancet, ii, 369.
    6. Berger JR, Globus M, Melamed E (1979). Acute transitory cerebellar dysfunction associated with piperazine adipate. Arch Neurol, 36, 180–181.
    7. Bomb RS, Bedi HK (1976). Neurotoxic side-effects of piperazine. Trans R Soc Trop Med Hyg, 70, 358.
    8. Gupta SR (1976). Piperazine neurotoxicity and psychological reaction. J Ind Med Ass, 66, 33–34.
    9. Parsons AC (1971). Piperazine neurotoxicity. ‘Worm wobble’. BMJ, 4, 790–792.
    10. Vallat JN, Vallat JM, Texier J, Léger J (1972). Les signes neurologiques d’intoxication par la piperazine. Bordeaux Médicale, 5, 394–400.
    11. Nickey LN (1966). Possible precipitation of petit mal seizures with piperazine citrate. J Am Med Ass, 195, 193–194.
    12. Buchanan N, Cassel R, Jenkins T (1971). G-6-PD deficiency and piperazine. BMJ, 2, 110.
    13. Hamlyn AN, Morris JS, Sarkany I, Sherlock S (1976). Piperazine hepatitis. Gastroenterology, 70, 1144–1147.
    14. Bellander T, sterdahl B-G, Hagmar L (1985). Formation of N-mononitrosopiperazine in the stomach and its excretion in the urine after oral intake of piperazine. Toxicol Appl Pharmacol, 80, 193–198.
    15. Sturman G (1973). Interaction between piperazine and chlorpromazine. Br J Pharmacol, 50, 153–155.
  • Flammability and hazardous characteristics Combustible; decomposition of toxic nitric oxide gas in case of thermal
  • Storage characteristics Treasury ventilation low-temperature drying; and stored separately from acid
  • Extinguishing agent Water spray, dry powder, carbon dioxide, alcohol-resistant foam
  • Professional standards TWA 1 mg/m³; STEL 5 mg/m
  • Description Piperazine is contained in pyrazinobutazone, an equimolecular sah of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory, in nurses and in veterinarians.
  • Chemical Properties Colorless to yellow solid; salty taste.
  • Chemical Properties Piperazine is white to cream-colored needles or powder. Characteristic ammonia-like odor. Combustible solids that do not easily ignite.
  • Uses Labelled Piperazine
  • Uses keratolytic, antiseborheic
  • Uses Piperazine is used as an intermediate in themanufacture of dyes, pharmaceuticals, polymers,surfactants, and rubber accelerators.
  • Indications Piperazine (Vermizine) contains a heterocyclic ring that lacks a carboxyl group. It acts on the musculature of the helminths to cause reversible flaccid paralysis mediated by chloride-dependent hyperpolarization of the muscle membrane. This results in expulsion of the worm. Piperazine acts as an agonist at gated chloride channels on the parasite muscle.
    Piperazine has been used with success to treat A. lumbricoides and E. vermicularis infections, although mebendazole is now the agent of choice. Piperazine is administered orally and is readily absorbed from the intestinal tract. Most of the drug is excreted in the urine within 24 hours.
    Piperazine is an appropriate alternative to mebendazole for the treatment of ascariasis, especially in the presence of intestinal or biliary obstruction. Cure rates of more than 80% are obtained following a 2-day regimen.
    Side effects occasionally include gastrointestinal distress, urticaria, and dizziness. Neurological symptoms of ataxia, hypotonia, visual disturbances, and exacerbations of epilepsy can occur in patients with preexisting renal insufficiency. It should not be used in pregnant women because of the formation of a potentially carcinogenic and teratogenic nitrosamine metabolite. Concomitant use of piperazine and chlorpromazine or pyrantel should be avoided.
  • Definition ChEBI: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.
  • brand name Pincets (Marion Merrell Dow); Pinsirup (Marion Merrell Dow);Adelmintex;Adipalis;Adipalit;Adiver;Ancaris thenium;Ancazine;Antelmina;Antepar (b-w);Anterobius;Anthalazine;Anthelmina;Anticucs;Antivermine;Ascalix;Ascarinex;Ascarivet;Asca-trol no.3;Asepar;Askaripar;Averamexan;Bel-zine;Bioxurin;B-piperazine;Brirel;Candizine;Carudol;Ciperazin;Citrazine;Coopane;Dak;Demovermil;Diatesurico;Dicevermin;Digesan;Dilaurazine;Dispermin;Diurazina;Dowzene;Ecosan;Endorid;Entazin;Equizole-a;Escovermin;Esteropipate;Etaphylline (acetyllinate);Gentiazina;Glycopiparsol;Heksapar;Helmacid;Helmezin;Helmicide;Helmifren;Helmipar;Helmirazine (adipate);Helmirazine (citrate);Helmitin;Helmizin;Herb royal round worm treatment;Hexanthelin;Ismiverm;Janes liquid permifu;Jarabe neox;Jetsan supp. (adipate);Justalmin;Kennel-maid;Kihomato;Kontipar;Lamboxil;Lombricida tropico;Lombrifher;Lombrikal;Lombrimade;Mapiprin;Maskito;Noxiurotan;Ogen;Okuside;Optiverm;Oxiril syrup (hydrate);Oxiuran (hydrate);Oxiurasin;Oxiustip elix;Oxivermin;Oxizin;Oxucid;Oxuril;Oxypip;Oxyzin;P.c. (citrate);Padrax;Paravermin;Pariamate;Par-tega;Perin;Piavermit;Pincide;Pipan;Pip-a-ray;Pipenin;Piperacid;Piperamicin;Piperascat;Piperaskat;Piperate;Piperaverm;Piperazinal;Piperazine (adipate);Pipercrean;Piperex;Piperiod;Piperital od;Piperitol;Piper-jodina;Piperol fort;Piperone;Piperoverm;Pipertox;Piperver;Piperzinal;Pipeverm;Pipezol;Pipizan citrate;Pipracid;Piprazid;Piprazyl;Pipricide;Piptelate;Piverma;Polo-verm;Polyquil;Pripsen;Provtovermil;Razinol;Rondelim;Rondoxyl;Santoban;Siropar;Supraverm;Taenifigin;Teniver;Tivazine;Toxocan;Uricida;Uridina;Uroclear (hexamine);Urodan (phosphate);Urosolvina;Uvilon syrup (hydrate);Vanpar (hydrate);Veripar;Vermazine;Vermenter;Vermicompren;Vermidol;Vermifug;Vermilass;Vermipan;Vermiphsarmette;Vermiquimpe;Vermiquimyc;Vermisit;Vermitox;Vermofrik;Verocid;Wairmex;Wurmex;Wurmsirup siegfried Multifuge;Multifuj;Nea-vermiol;Nemafugan;Nemasin;Nematocton;Nematorazine;Neo-ifusa;.
  • World Health Organization (WHO) Piperazine was first used as a treatment for gout earlier this century and its anthelminthic activity was discovered in 1949. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworm it has been withdrawn from use on the grounds that other more effective and less toxic drugs are now available (see full list). In other such countries, however, piperazine remains available in over-the-counter preparations. Clinical dosages occasionally induce transient neurological signs and concern has been expressed that in some circumstances the drug may generate small amounts of nitrosamine in the stomach. However, it is widely considered that these trace doses are unlikely to give rise to a significant carcinogenic potential. (Reference: (WHODIB) WHO Drug Information Bulletin, 1: 5, , 1983)
  • General Description Needle-like white or colorless crystals. Shipped as a solid or suspended in a liquid medium. Very corrosive to skin, eyes and mucous membranes. Solid turns dark when exposed to light. Flash point 190°F. Used as a corrosion inhibitor and as an insecticide.
  • Air & Water Reactions Flammable. Absorbs water and carbon dioxide from air. Soluble in water.
  • Reactivity Profile 1,4-Diazacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. 1,4-Diazacyclohexane is sensitive to light; 1,4-Diazacyclohexane absorbs water and carbon dioxide from air. 1,4-Diazacyclohexane may be corrosive to aluminum, magnesium and zinc. .
  • Health Hazard TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
  • Health Hazard Piperazine is a corrosive substance. The solidand its concentrated aqueous solutions areirritants to the skin and eyes. The irritanteffect in rabbits’ eyes was severe.
    The toxic symptoms from ingestion ofpiperazine include nausea, vomiting, excitement,change in motor activity, somnolence,and muscle contraction. The toxicity of thiscompound is low, however. The oral LD50value in rats is 1900 mg/kg. The inhalationtoxicity is very low. The inhalation LC50value in mice is 5400 mg/m3/2 h.
  • Fire Hazard Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
  • Pharmaceutical Applications A synthetic chemical, most commonly formulated as the citrate, but also available as the adipate, edetate calcium and tartrate salts.
  • Contact allergens Piperazine is contained in pyrazinobutazone, an equimolar salt of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory workers, in nurses, and in veterinarians.
  • Pharmacokinetics Activity against intestinal worms requires that a substantial amount remains in the gut. However, after oral administration a variable amount is rapidly absorbed from the small intestine and subsequently excreted in the urine. Its half-life is extremely variable.
  • Clinical Use Hexahydropyrazine or diethylenediamine (Arthriticine,Dispermin) occurs as colorless, volatile crystals of the hexahydratethat are freely soluble in water. After the discoveryof the anthelmintic properties of a derivative diethylcarbamazine,the activity of piperazine itself was established.Piperazine is still used as an anthelmintic for the treatmentof pinworm (Enterobius [Oxyuris] vermicularis) and roundworm(Ascaris lumbricoides) infestations. It is available invarious salt forms, including the citrate (official in the USP)in syrup and tablet forms. Piperazine blocks the response of the ascaris muscleto acetylcholine, causing flaccid paralysis in the worm,which is dislodged from the intestinal wall and expelled inthe feces.
  • Clinical Use Ascariasis
    Pinworm
  • Side effects Some people develop hypersensitivity, requiring cessation of treatment. Transient, mild gastrointestinal or neurological symptoms may occur.
  • Safety Profile Moderately toxic by ingestion, skin contact, intravenous, and subcutaneous routes. Mildly toxic by inhalation. A skin and severe eye irritant. Excessive absorption can cause urticaria, vomiting, diarrhea, blurred vision, and weakness. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Explodes on contact with dicyanofurazan. To fight fire, use alcohol foam, mist, dry chemical, water spray. When heated to decomposition it emits highly toxic fumes of NOx.
  • Potential Exposure (Piperazine): Primary irritant (w/o allergic reaction),
  • Veterinary Drugs and Treatments Piperazine is used for the treatment of ascarids in dogs, cats, horses, swine and poultry. Piperazine is considered safe to use in animals with concurrent gastroenteritis and during pregnancy.
  • Carcinogenicity No increase in lung adenomas was produced in mice administered 0.69–18.75mg of piperazine/ kg in drinking water for 20–25 weeks and sacrificed 10–13 weeks later. Mice fed the equivalent of 938 mg/kg in the diet for 28 weeks and sacrificed at 40 weeks failed to show any significant increase in the incidence of lung adenomas. An increase in lung adenomas was produced in this bioassay by administration of piperazine together with sodium nitrate, suggesting the formation of the active nitroso derivative. Sodium ascorbate inhibited tumor formation, in theory, by preventing piperazine nitrosation (304). Coadministration of 250 ppm piperazine and 500 ppm sodium nitrate in drinking water did not produce tumors in rats. None of these studies were conducted using currently accepted methods for evaluating carcinogenic potential but piperazine alone, in these assays, was noncarcinogenic.
  • Shipping UN2579 Piperazine, Hazard class: 8; Labels: 8-Corrosive material.
  • Purification Methods Piperazine crystallises from EtOH or anhydrous *benzene and is dried at 0.01mm. It can be sublimed under vacuum and purified by zone melting. The hydrochloride has m 172-174o (from EtOH), and the dihydrochloride crystallises from aqueous EtOH and has m 318-320o (dec, sublimes at 295-315o). The picrate has m ~200o, and the picrolonate crystallises from dimethylformamide ( m 259-261o). [Beilstein 23 H 4, 23 I 4, 23 II 3, 23 III/IV 15, 23/1 V 30.]
  • Incompatibilities Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.
Piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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110-85-0, PiperazineRelated Search:
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  • Piperazine,99%,extra pure
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