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ChemicalBook >> CAS DataBase List >>Piperazine

Piperazine suppliers

Piperazine

CAS:: 110-85-0

MF:: C4H10N2

MW:: 86.14

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H315-H319

Precautionary statements ：: P305+P351+P338

Hazard Codes ：: C,Xn

Risk Statements ：: 34-42/43-52/53-62-52-63

Safety Statements ：: 22-26-36/37/39-45-61

RIDADR ：: UN 2579 8/PG 3

WGK Germany ：: 1

RTECS ：: TK7800000

F ：: 3-8-23

Hazard Note ：: Harmful/Corrosive

TSCA ：: Yes

HS Code ：: 2933 59 95

HazardClass ：: 8

PackingGroup ：: III

Toxicity：: LD50 orally in Rabbit: 2600 mg/kg LD50 dermal Rabbit 8300 mg/kg

Use：: Piperazine was first used as a treatment for gout earlier this century and its anthelminthic activity was discovered in 1949. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworm it has been withdrawn from use on the grounds that other more effective and less toxic drugs are now available (see full list). In other such countries, however, piperazine remains available in over-the-counter preparations. Clinical dosages occasionally induce transient neurological signs and concern has been expressed that in some circumstances the drug may generate small amounts of nitrosamine in the stomach. However, it is widely considered that these trace doses are unlikely to give rise to a significant carcinogenic potential. (Reference: (WHODIB) WHO Drug Information Bulletin, 1: 5, , 1983)

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