Basic information Safety Related Supplier

Amoxapine

Basic information Safety Related Supplier
Amoxapine Basic information
Amoxapine Chemical Properties
  • Melting point:175-1760C
  • Boiling point:469.9±55.0 °C(Predicted)
  • Density 1.2613 (rough estimate)
  • refractive index 1.5800 (estimate)
  • Flash point:9℃
  • storage temp. -20°C Freezer
  • solubility methanol: soluble
  • pkapKa 7.6 (Uncertain)
  • color Crystals from benzene/pet ether
  • Merck 14,576
  • CAS DataBase Reference14028-44-5(CAS DataBase Reference)
  • NIST Chemistry ReferenceAmoxapine(14028-44-5)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22
  • Safety Statements 36
  • RIDADR 3249
  • WGK Germany 3
  • RTECS HQ4025500
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 2934990002
  • ToxicityLD50 in mice (mg/kg): 122 i.p.; 112 orally (Howell, 1972)
MSDS
Amoxapine Usage And Synthesis
  • Chemical PropertiesCrystalline Solid
  • Usesantidepressant, inhibits norepinephrine uptake
  • DefinitionChEBI: A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.
  • brand nameAsendin (Lederle).
  • General DescriptionConsideration of the structure of amoxapine, 2-chloro-11-(1-piperazinyl)dibenz-[b,f] [1,4]oxazepine (Asendin), reinforcesthe fact that many antidepressants are very closelyrelated to antipsychotics. Indeed, some, including amoxapine,have significant effects at D2 receptors. The Nmethyl–substituted relative of amoxapine is the antipsychoticloxapine (Loxitane). The 8-hydroxy metabolite ofamoxapine is reportedly active as an antidepressant and asa D2 receptor blocker.
  • Safety ProfilePoison by ingestion andintraperitoneal routes. Human systemic effects byingestion: acute renal failure, acute tubular necrosis, BPlowering, coma, convulsions, decreased body temperature,EKG changes, excitement, fasciculations, heart ratechanges, hype
Amoxapine Preparation Products And Raw materials
Amoxapine(14028-44-5)Related Product Information
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