4-Hydroxypyrimidine

Description

Pyrimidone(4-Hydroxypyrimidine) is the name given to either of two heterocyclic compounds with the formula C4H4N2O: 2-pyrimidone and 4-pyrimidone. The compounds can also be called 2-hydroxypyrimidine or 4-hydroxypyrimidine respectively, based on a substituted pyrimidine, or 1, 3-diazine, ring. 4-pyrimidinone is an important bioactive molecule with various biological activities such as anti-virus, anti-tumor, induction of interferon production and immune regulation.

Chemical Properties

white to slightly yellow powder

Uses

4(3H)-pyrimidinone heterocyclic compounds and their pharmaceutically usable salts can be used to treat and/or prevent SHP2-mediated conditions, particularly in cancer clinical drug research. Furthermore, based on a series of studies on 4(3H)-pyrimidinones and their derivatives (such as 4-Hydroxypyrimidine), some substances have been found to act as modulators of the TRPV4 receptor, exhibiting promising properties in the treatment of various diseases and syndromes, especially in the treatment of inflammatory, painful, and urinary disorders and dysregulation.

Hazard

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Enzyme inhibitor

This hygroscopic pyrimidine, also known as 4-hydroxypyrimidine and 4- pyrimidinol (FW = 96.09 g/mol), inhibits both hypoxanthine(guanine) and xanthine phosphoribosyltransferases.