ChemicalBook > CAS DataBase List > L-Tetrahydrofolic Acid

L-Tetrahydrofolic Acid

L-Tetrahydrofolic Acid Structure
L-Tetrahydrofolic Acid
  • CAS No.135-16-0
  • Chemical Name:L-Tetrahydrofolic Acid
  • CBNumber:CB6259109
  • Molecular Formula:C19H23N7O6
  • Formula Weight:445.43
  • MOL File:135-16-0.mol
L-Tetrahydrofolic Acid Property
  • Boiling point: :555.12°C (rough estimate)
  • Density  :1.4216 (rough estimate)
  • refractive index  :1.6800 (estimate)
  • storage temp.  :-20°C
  • form  :powder
  • pka :3.51±0.10(Predicted)
  • color  :off-white to tan
  • BRN  :9238187
  • Stability: :We have observed that this material decomposes steadily over time. Use immediately upon receipt.
  • FDA UNII :43ZWB253H4
Safety
  • WGK Germany  :3
  • RTECS  :MA0600800
  • F  :3-8-10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
L-Tetrahydrofolic Acid Price More Price(18)
  • Brand: Sigma-Aldrich
  • Product number: T3125
  • Product name : Tetrahydrofolic acid
  • Purity: ≥65% (when packaged), powder
  • Packaging: 25mg
  • Price: $54.6
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: T3125
  • Product name : Tetrahydrofolic acid
  • Purity: ≥65% (when packaged), powder
  • Packaging: 1g
  • Price: $770
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: T293515
  • Product name : L-TetrahydrofolicAcid(>70%whenpackaged)
  • Purity: 
  • Packaging: 100mg
  • Price: $410
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Usbiological
  • Product number: 366599
  • Product name : Tetrahydrofolic Acid
  • Purity: 
  • Packaging: 96Tests
  • Price: $954
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: American Custom Chemicals Corporation
  • Product number: AAA0009069
  • Product name : TETRAHYDROFOLIC ACID
  • Purity: 95.00%
  • Packaging: 500MG
  • Price: $1035
  • Updated: 2021/12/16
  • Buy: Buy

L-Tetrahydrofolic Acid Chemical Properties,Usage,Production

  • Chemical Properties Light Tan Solid
  • Uses Asa folic acid derivative and coenzyme, L-Tetrahydrofolic Acid can be involved in the metabolism of amino and nucleic acids.
  • Uses L-Tetrahydrofolic Acid is a folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids. We have observed that this material decomposes steadily over time. Use immediately upon receipt.
  • Definition ChEBI: A derivative of folic acid in which the pteridine ring is fully reduced; it is the parent compound of a variety of coenzymes that serve as carriers of one-carbon groups in metabolic reactions.
  • Purification Methods Very high quality material is now available commercially, and it should be a white powder. It can be dried over P2O5 in a vacuum desiccator and stored in weighed aliquots in sealed ampoules. It is stable at room temperature in sealed ampoules for many months and for much more extended periods at -10o. When moist, it is extremely sensitive to air whereby it oxidises to the yellow 7,8-dihydro derivative. In solution it turns yellow in colour as it oxidises, and then particularly in the presence of acids it turns dark reddish brown in colour. Hence aqueous solutions should be frozen immediately when not in use. It is always advisable to add 2-mercaptoethanol (if it does not interfere with the procedure for which it is used) which stabilises it by depleting the solution of O2. The sulfate salt is more stable but is much less soluble. The best way to prepare standard solutions of this acid is to dissolve it in the desired buffer and estimate the concentration by UV absorption in pH 7 buffer at 297nm ( 22,000 M-1cm-1). If a sample is suspect, it is not advisable to purify it because it is likely to deteriorate further as “dry box” conditions are necessary. Either a new sample is purchased or one is freshly prepared from folic acid. It has the above pKa values. [Hafeti et al. Biochemical Preparations 7 89 1960, UV: Mathews & Huennekens J Biol Chem 235 3304 1960, Osborn & Huennekens J Biol Chem 233 969 1958, O'Dell et al. J Am Chem Soc 69 250 1947, Blakley Biochem J 6 5 331 1957, Asahi Yakugaku Zasshi (J Pharm Soc Jpn) 79 1548 1959, Beilstein 26 III/IV 3879.]
L-Tetrahydrofolic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
Global(84)Suppliers
  • Supplier:
    Standardpharm Co. Ltd.
  • Tel:86-714-3992388
  • Fax:
  • Email:overseasales1@yongstandards.com
  • Country:United States
  • ProdList:14344
  • Advantage:58
  • Supplier:
    BOC Sciences
  • Tel:1-631-485-4226
  • Fax:1-631-614-7828
  • Email:inquiry@bocsci.com
  • Country:United States
  • ProdList:19752
  • Advantage:58
  • Supplier:
    career henan chemical co
  • Tel:15093356674 0371-55982848
  • Fax:0086-371-86658258
  • Email:factory@coreychem.com
  • Country:CHINA
  • ProdList:29863
  • Advantage:58
  • Supplier:
    Zhengzhou Alfa Chemical Co.,Ltd
  • Tel:+8613343822234 +86-0371-55052911
  • Fax:
  • Email:sales5@alfachem.cn;sales9@alfachem.cn;sale1@alfachem.cn
  • Country:China
  • ProdList:12871
  • Advantage:58
  • Supplier:
    Creative Enzymes
  • Tel:1-631-619-7922
  • Fax:1-631-938-8127
  • Email:info@creative-enzymes.com
  • Country:United States
  • ProdList:8748
  • Advantage:58
  • Supplier:
    Hubei Ipure Biology Co., Ltd
  • Tel:+8618062405514
  • Fax:18062427325
  • Email:ada@ipurechemical.com;ada@ipurechemical.com
  • Country:China
  • ProdList:10352
  • Advantage:58
135-16-0, L-Tetrahydrofolic AcidRelated Search:
  • L-5,6,7,8-Tetrahydrofolic acid
  • Tetrahydropteroylglutaamic acid
  • (6S)-Tetrahydrofolic acid
  • (6S)-Thfa
  • C00101
  • Tetrahydrofolic acid,5,6,7,8-Tetrahydropteroyl-L-glutamic acid, THF
  • L-Tetrahydrofolic Acid, synthesized on receipt of order. 95% MiniMuM purity when shipped.
  • (-)-L-5,6,7,8-Tetrahydrofolic acid
  • THFA Tetrahydrofolic acid
  • Folic Acid Impurity 11
  • 2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
  • Tetrahydrofolic acid 5,6,7,8-Tetrahydropteroyl-L-glutamic acid
  • tetrahydrofolic acid dihydrochloride dihydrate
  • tetrahydrofolic acid sealed ampule
  • N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
  • Tetrahydrofolic acide
  • L-Tetrahydrofolic Acid
  • (2S)-2-(4-(((2-Amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
  • -2-(4-(((2-Amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)
  • Tetrahydofolic acid
  • 5,6,7,8-tetrahydrofolicacid
  • glutamicacid,n-(p-(((2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)
  • l-amino)benzoyl)
  • tetrahydropteroylglutamicacid
  • 5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID
  • TETRAHYDROFOLIC ACID
  • N-[4-[[(2-AMino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid
  • (2S)-2-(4-(((2-aMino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
  • L-Tetrahydrofolic Acid (&gt
  • 70% when packaged)
  • L-Glutamic acid, N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
  • L-Tetrahydrofolic Acid USP/EP/BP
  • L-Tetrahydrofolic Acid (>70% when packaged)
  • 135-16-0
  • C19H23N7O6
  • Enzymes, Inhibitors, and Substrates
  • Cofactor
  • Cofactors
  • Metabolites and Cofactors on the Metabolic Pathways Chart
  • Metabolic Pathways
  • Metabolomics
  • Oxidation-Reduction
  • Biochemicals and Reagents
  • BioChemical
  • Folic
  • co-factor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents