Chemical Properties
yellow to orange powder
Uses
Sepiapterin can be used to induce sequence-specific photolesions in double-stranded DNA.
Uses
L-Sepiapterin serves as a substrate for BH4 synthesis via the pterin salvage pathway. It inhibits rat liver GTP cyclohydrolase with an IC50 value of approximately 25 μM. It can be used to circumvent the inhibition of pterin biosynthesis by 2,4-diamino-6-hydroxy pyrimidine.[Cayman Chemical]
Uses
Sepiapterin improved the endothelial dysfunction in SMA from db/db mice by decreasing oxidative stress. Sepiapterin is commonly used in the study for treamtment of Type I Diabetes
Definition
ChEBI: L-sepiapterin is a sepiapterin with L configuration.
General Description
Sepiapterin, a pteridine derivative, is a stable precursor of tetrahydrobiopterin (BH
4). It is a yellow pigment found in
sepia mutant of
Drosophila melanogaster and lemon
Bombyx mori mutant (silkworm).
Biochem/physiol Actions
Cofactor of nitric oxide synthase; intracellularly converted to tetrahydro-biopterin leading to the stimulation of nitric oxide.
