ChemicalBook > CAS DataBase List > 10-Hydroxycamptothecin

10-Hydroxycamptothecin

CAS No.19685-09-7
Chemical Name:10-Hydroxycamptothecin
CBNumber:CB4445430
Molecular Formula:C20H16N2O5
Formula Weight:364.35
MOL File:19685-09-7.mol

10-Hydroxycamptothecin Property

Melting point 265-270°C
Boiling point 820.7±65.0 °C(Predicted)
Density 1.60
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka 8.93±0.40(Predicted)
InChIKey HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference 19685-09-7(CAS DataBase Reference)

Safety

Safety Statements :24/25
HS Code :29349990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

10-Hydroxycamptothecin Price More Price(46)

Brand: Sigma-Aldrich
Product number: PHR2491
Product name : Irinotecan Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 25MG
Price: $424
Updated: 2022/05/15
Buy: Buy

Brand: Sigma-Aldrich
Product number: 1347610
Product name : Irinotecan Related Compound A
Purity:
Packaging: 10mg
Price: $1370
Updated: 2022/05/15
Buy: Buy

Brand: TCI Chemical
Product number: H1463
Product name : 10-Hydroxycamptothecin
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $201
Updated: 2022/04/27
Buy: Buy

Brand: Cayman Chemical
Product number: 14635
Product name : (S)-10-hydroxy-Camptothecin
Purity: ≥98%
Packaging: 25mg
Price: $50
Updated: 2022/04/27
Buy: Buy

Brand: Cayman Chemical
Product number: 14635
Product name : (S)-10-hydroxy-Camptothecin
Purity: ≥98%
Packaging: 50mg
Price: $94
Updated: 2022/04/27
Buy: Buy

10-Hydroxycamptothecin Chemical Properties,Usage,Production

Description DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G₂/M phase.
Chemical Properties Yellow Solid
Uses A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy

10-Hydroxycamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

10-Hydroxycamptothecin Suppliers

Global(389)Suppliers

Canada 1 China 316 Europe 2 Germany 3 India 7 Japan 2 South Korea 1 The Netherlands 1 Ukraine 1 United Kingdom 7 United States 48 Global 389

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Accela ChemBio Inc.
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10-Hydroxycamptothecin Spectrum

19685-09-7, 10-HydroxycamptothecinRelated Search:

sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate Irinotecan 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 6 Irinotecan EP Impurity H 12-Hydroxy Irinotecan 7-Ethylcamptothecin Irinotecan EP Impurity K (Mixture of Diastereomers) Irinotecan IMpurity G Irinotecan Impurity 5 RPR 121056 GURKHSYORGJETM-MGDILKBHSA-N 12-ethyl-8-methyl-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate Irinotecan Impurity 26 11-Desethyl Irinotecan Irinotecan Impurity 3 Irinotecan Hydroxyl Acid Irinotecan Impurity 2

Camptothecae Acuminatae extract
hydrate,(s)-dihydroxy
hydroxy-camptotheci
Hydroxycamptothencine
(20S)-10-HYDROXYCAMPTOTHECIN 98%
(20S)-10-Hydroxycamptothecin
HYDROCAMPTOTHECINE
CAMPTOTHECIN, 10-HYDROXY(SH)
HYDROXYCAMPTOTHECIN, 10-(P)
10-hydroxycamptothecin (TECANS)
10-HYDROCAMPTOTHECIN
Ampule
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
NSC 107124
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,10-dihydroxy-, (4S)-
(4S)-4,9-Dihydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(S)-10-HYDROXYCAMPTOTHECIN
SN38
10-Hydroxycamptothecin, 98%, from Taxus chinensis (Pilg.) Rehder
10-HCPT
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
(S)-10-Hydroxycamptothecin (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Irinotecan USP RC A
Irinotecan Impurity 12
CAMPTOTHECIN, 10-HYDROXY-
CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA
HCPT
HYDROXYCAMPTOTHECIN
HYDROXYCAMPTOTHECIN, 10-
(20S)-10-HYDROXYCAMPTOTHECIN (20S)-7-ETHYL-10-HYDROXYCAMPTOTHECIN (S)-10-HYDROXYCAMPTOTHECIN
CaMptothecin IMpurity
CaMptothecin 10-Hydroxy IMpurity
10-HydroxycaMptothecin, froM Taxus chinensis
Irinotecan EP Impurity B
10-Hydroxycamptothecin 19685-09-7
(S)-4-ethyl-4,9-dihydroxy-1H-pyrano
10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY B)
Fructus Camptothecae
(s)-10-hydroxycamptothecinhydrate
4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-1h-pyrano(3
4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-dihydroxy-,hydrate,(s)-1h-pyrano(3
(4S)-4α-Ethyl-4,9-dihydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
(4S)-9-Hydroxy-4-hydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
10-Hydroxycamptothecin
10-Hydroxycamptothecine
HYDROXYCAMPTOTHECIN, 10-(RG)
10-hydroxycamptothecin,HCPT
(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
Irinotecan Related CoMpound A
(+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
Irinotecan Related Compound A (10 mg) ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
10-HydroxycaMptothecin, HydroxycaMptothecine
Hydroxycamptothecin 80-98%
(S)-10-Hydroxycamptothecin,>98%
(20S)-10-Hydroxycamptothecine
Camptotheca acuminata fruit extract
(19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

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