ChemicalBook > CAS DataBase List > 10-Hydroxycamptothecin
10-Hydroxycamptothecin
10-Hydroxycamptothecin
- CAS No.19685-09-7
- Chemical Name:10-Hydroxycamptothecin
- CBNumber:CB4445430
- Molecular Formula:C20H16N2O5
- Formula Weight:364.35
- MOL File:19685-09-7.mol
10-Hydroxycamptothecin Property
- Melting point 265-270°C
- Boiling point 820.7±65.0 °C(Predicted)
- Density 1.60
- storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka 8.93±0.40(Predicted)
- InChIKey HAWSQZCWOQZXHI-FQEVSTJZSA-N
- CAS DataBase Reference 19685-09-7(CAS DataBase Reference)
Safety
- Safety Statements :24/25
- HS Code :29349990
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
10-Hydroxycamptothecin Price
More Price(46)
- Brand: Sigma-Aldrich
- Product number: PHR2491
- Product name : Irinotecan Related Compound A
- Purity: Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging: 25MG
- Price: $424
- Updated: 2022/05/15
- Buy: Buy
- Brand: Sigma-Aldrich
- Product number: 1347610
- Product name : Irinotecan Related Compound A
- Purity:
- Packaging: 10mg
- Price: $1370
- Updated: 2022/05/15
- Buy: Buy
- Brand: TCI Chemical
- Product number: H1463
- Product name : 10-Hydroxycamptothecin
- Purity: >98.0%(HPLC)
- Packaging: 1g
- Price: $201
- Updated: 2022/04/27
- Buy: Buy
- Brand: Cayman Chemical
- Product number: 14635
- Product name : (S)-10-hydroxy-Camptothecin
- Purity: ≥98%
- Packaging: 25mg
- Price: $50
- Updated: 2022/04/27
- Buy: Buy
- Brand: Cayman Chemical
- Product number: 14635
- Product name : (S)-10-hydroxy-Camptothecin
- Purity: ≥98%
- Packaging: 50mg
- Price: $94
- Updated: 2022/04/27
- Buy: Buy
10-Hydroxycamptothecin Chemical Properties,Usage,Production
-
Description
DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-
strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways.1 (S)- 10- hydroxy- Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound.2 (S)- 10- hydroxy- Camptothecin has strong anti- tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM).2 In vitro treatment of human HepG2 cells with 5- 20 μM (S)- 10- hydroxy- camptothecin results in cell cycle arrest at the G2/M phase.3 - Chemical Properties Yellow Solid
- Uses A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy
10-Hydroxycamptothecin Preparation Products And Raw materials
Raw materials
Preparation Products
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19685-09-7, 10-HydroxycamptothecinRelated Search:
- sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate Irinotecan 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 6 Irinotecan EP Impurity H 12-Hydroxy Irinotecan 7-Ethylcamptothecin Irinotecan EP Impurity K (Mixture of Diastereomers) Irinotecan IMpurity G Irinotecan Impurity 5 RPR 121056 GURKHSYORGJETM-MGDILKBHSA-N 12-ethyl-8-methyl-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate Irinotecan Impurity 26 11-Desethyl Irinotecan Irinotecan Impurity 3 Irinotecan Hydroxyl Acid Irinotecan Impurity 2
- Camptothecae Acuminatae extract
- hydrate,(s)-dihydroxy
- hydroxy-camptotheci
- Hydroxycamptothencine
- (20S)-10-HYDROXYCAMPTOTHECIN 98%
- (20S)-10-Hydroxycamptothecin
- HYDROCAMPTOTHECINE
- CAMPTOTHECIN, 10-HYDROXY(SH)
- HYDROXYCAMPTOTHECIN, 10-(P)
- 10-hydroxycamptothecin (TECANS)
- 10-HYDROCAMPTOTHECIN
- Ampule
- (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- NSC 107124
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,10-dihydroxy-, (4S)-
- (4S)-4,9-Dihydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (S)-10-HYDROXYCAMPTOTHECIN
- SN38
- 10-Hydroxycamptothecin, 98%, from Taxus chinensis (Pilg.) Rehder
- 10-HCPT
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
- (S)-10-Hydroxycamptothecin (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- Irinotecan USP RC A
- Irinotecan Impurity 12
- CAMPTOTHECIN, 10-HYDROXY-
- CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA
- HCPT
- HYDROXYCAMPTOTHECIN
- HYDROXYCAMPTOTHECIN, 10-
- (20S)-10-HYDROXYCAMPTOTHECIN (20S)-7-ETHYL-10-HYDROXYCAMPTOTHECIN (S)-10-HYDROXYCAMPTOTHECIN
- CaMptothecin IMpurity
- CaMptothecin 10-Hydroxy IMpurity
- 10-HydroxycaMptothecin, froM Taxus chinensis
- Irinotecan EP Impurity B
- 10-Hydroxycamptothecin 19685-09-7
- (S)-4-ethyl-4,9-dihydroxy-1H-pyrano
- 10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY B)
- Fructus Camptothecae
- (s)-10-hydroxycamptothecinhydrate
- 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-1h-pyrano(3
- 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-dihydroxy-,hydrate,(s)-1h-pyrano(3
- (4S)-4α-Ethyl-4,9-dihydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
- (4S)-9-Hydroxy-4-hydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-Hydroxycamptothecin
- 10-Hydroxycamptothecine
- HYDROXYCAMPTOTHECIN, 10-(RG)
- 10-hydroxycamptothecin,HCPT
- (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
- Irinotecan Related CoMpound A
- (+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
- Irinotecan Related Compound A (10 mg) ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-HydroxycaMptothecin, HydroxycaMptothecine
- Hydroxycamptothecin 80-98%
- (S)-10-Hydroxycamptothecin,>98%
- (20S)-10-Hydroxycamptothecine
- Camptotheca acuminata fruit extract
- (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione