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10-Hydroxycamptothecin

10-Hydroxycamptothecin Structure
10-Hydroxycamptothecin
  • CAS No.19685-09-7
  • Chemical Name:10-Hydroxycamptothecin
  • CBNumber:CB4445430
  • Molecular Formula:C20H16N2O5
  • Formula Weight:364.35
  • MOL File:19685-09-7.mol
10-Hydroxycamptothecin Property
  • Melting point 265-270°C
  • Boiling point 820.7±65.0 °C(Predicted)
  • Density 1.60
  • storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
  • pka 8.93±0.40(Predicted)
  • InChIKey HAWSQZCWOQZXHI-FQEVSTJZSA-N
  • CAS DataBase Reference 19685-09-7(CAS DataBase Reference)
Safety
  • Safety Statements  :24/25
  • HS Code  :29349990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
10-Hydroxycamptothecin Price More Price(46)
  • Brand: Sigma-Aldrich
  • Product number: PHR2491
  • Product name : Irinotecan Related Compound A
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 25MG
  • Price: $424
  • Updated: 2022/05/15
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1347610
  • Product name : Irinotecan Related Compound A
  • Purity: 
  • Packaging: 10mg
  • Price: $1370
  • Updated: 2022/05/15
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: H1463
  • Product name : 10-Hydroxycamptothecin
  • Purity: >98.0%(HPLC)
  • Packaging: 1g
  • Price: $201
  • Updated: 2022/04/27
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 14635
  • Product name : (S)-10-hydroxy-Camptothecin
  • Purity: ≥98%
  • Packaging: 25mg
  • Price: $50
  • Updated: 2022/04/27
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 14635
  • Product name : (S)-10-hydroxy-Camptothecin
  • Purity: ≥98%
  • Packaging: 50mg
  • Price: $94
  • Updated: 2022/04/27
  • Buy: Buy

10-Hydroxycamptothecin Chemical Properties,Usage,Production

  • Description DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.
  • Chemical Properties Yellow Solid
  • Uses A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy
10-Hydroxycamptothecin Preparation Products And Raw materials
Raw materials
Preparation Products
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10-Hydroxycamptothecin Spectrum
19685-09-7, 10-HydroxycamptothecinRelated Search:
  • Camptothecae Acuminatae extract
  • hydrate,(s)-dihydroxy
  • hydroxy-camptotheci
  • Hydroxycamptothencine
  • (20S)-10-HYDROXYCAMPTOTHECIN 98%
  • (20S)-10-Hydroxycamptothecin
  • HYDROCAMPTOTHECINE
  • CAMPTOTHECIN, 10-HYDROXY(SH)
  • HYDROXYCAMPTOTHECIN, 10-(P)
  • 10-hydroxycamptothecin (TECANS)
  • 10-HYDROCAMPTOTHECIN
  • Ampule
  • (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • NSC 107124
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,10-dihydroxy-, (4S)-
  • (4S)-4,9-Dihydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-10-HYDROXYCAMPTOTHECIN
  • SN38
  • 10-Hydroxycamptothecin, 98%, from Taxus chinensis (Pilg.) Rehder
  • 10-HCPT
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
  • (S)-10-Hydroxycamptothecin (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • Irinotecan USP RC A
  • Irinotecan Impurity 12
  • CAMPTOTHECIN, 10-HYDROXY-
  • CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA
  • HCPT
  • HYDROXYCAMPTOTHECIN
  • HYDROXYCAMPTOTHECIN, 10-
  • (20S)-10-HYDROXYCAMPTOTHECIN (20S)-7-ETHYL-10-HYDROXYCAMPTOTHECIN (S)-10-HYDROXYCAMPTOTHECIN
  • CaMptothecin IMpurity
  • CaMptothecin 10-Hydroxy IMpurity
  • 10-HydroxycaMptothecin, froM Taxus chinensis
  • Irinotecan EP Impurity B
  • 10-Hydroxycamptothecin 19685-09-7
  • (S)-4-ethyl-4,9-dihydroxy-1H-pyrano
  • 10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY B)
  • Fructus Camptothecae
  • (s)-10-hydroxycamptothecinhydrate
  • 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-1h-pyrano(3
  • 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-dihydroxy-,hydrate,(s)-1h-pyrano(3
  • (4S)-4α-Ethyl-4,9-dihydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
  • (4S)-9-Hydroxy-4-hydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 10-Hydroxycamptothecin
  • 10-Hydroxycamptothecine
  • HYDROXYCAMPTOTHECIN, 10-(RG)
  • 10-hydroxycamptothecin,HCPT
  • (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
  • Irinotecan Related CoMpound A
  • (+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
  • Irinotecan Related Compound A (10 mg) ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
  • 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 10-HydroxycaMptothecin, HydroxycaMptothecine
  • Hydroxycamptothecin 80-98%
  • (S)-10-Hydroxycamptothecin,>98%
  • (20S)-10-Hydroxycamptothecine
  • Camptotheca acuminata fruit extract
  • (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione