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1,2-DIPALMITOYL-SN-GLYCEROL

1,2-DIPALMITOYL-SN-GLYCEROL Structure
1,2-DIPALMITOYL-SN-GLYCEROL
  • CAS No.30334-71-5
  • Chemical Name:1,2-DIPALMITOYL-SN-GLYCEROL
  • CBNumber:CB4228240
  • Molecular Formula:C35H68O5
  • Formula Weight:568.91
  • MOL File:30334-71-5.mol
1,2-DIPALMITOYL-SN-GLYCEROL Property
  • Melting point: :66-69 °C
  • Boiling point: :620.8±22.0 °C(Predicted)
  • Density  :0.930±0.06 g/cm3(Predicted)
  • storage temp.  :-20°C
  • pka :13.69±0.10(Predicted)
  • BRN  :1730209
Safety
  • WGK Germany  :1
  • F  :10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
1,2-DIPALMITOYL-SN-GLYCEROL Price More Price(19)
  • Brand: Sigma-Aldrich
  • Product number: D9135
  • Product name : 1,2-Dipalmitoyl-sn-glycerol
  • Purity: ≥99%
  • Packaging: 25mg
  • Price: $38.5
  • Updated: 2021/12/16
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  • Brand: Sigma-Aldrich
  • Product number: D9135
  • Product name : 1,2-Dipalmitoyl-sn-glycerol
  • Purity: ≥99%
  • Packaging: 100mg
  • Price: $102
  • Updated: 2021/12/16
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  • Brand: Cayman Chemical
  • Product number: 10008648
  • Product name : 1,2-Dipalmitoyl-sn-glycerol
  • Purity: ≥95%
  • Packaging: 25mg
  • Price: $15
  • Updated: 2021/12/16
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  • Brand: Cayman Chemical
  • Product number: 10008648
  • Product name : 1,2-Dipalmitoyl-sn-glycerol
  • Purity: ≥95%
  • Packaging: 50mg
  • Price: $25
  • Updated: 2021/12/16
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  • Brand: TRC
  • Product number: D486890
  • Product name : 1,2-Dipalmitoyl-sn-glycerol
  • Purity: 
  • Packaging: 100mg
  • Price: $85
  • Updated: 2021/12/16
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1,2-DIPALMITOYL-SN-GLYCEROL Chemical Properties,Usage,Production

  • Uses 1,2-Dipalmitoyl-sn-glycerol (1,2-DPG) is an analog of the protein kinase C (PKC)-activating second messenger diacylglycerol. 1,2-Dipalmitoyl-sn-glycerol is a weak activator of PKC.
  • Uses
    16:0 DG has been used to spike brain samples for mass spectrometric analysis. It may be used as diacyl-glycerol source in diacylglycerol O-acyltransferase 1 (DGAT1) enzyme assay in human leukemic?K562 cells and in Golgi-like liposomes reconstitution.
  • Definition ChEBI: A 1,2-diacyl-sn-glycerol in which both acyl groups are specified as palmitoyl (hexadecanoyl).
  • General Description
    In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.
    Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.
  • Biochem/physiol Actions 16:0 DG (1,2-dipalmitoyl-sn-glycerol) fails to prevent the late fission events in Golgi membrane. Supplementation of 16:0 DG promotes bacterial growth by preventing sporangia.
  • Purification Methods Crystallise S(-)-1,2-dipalmitin from chloroform/pet ether (b 40-60o) ~1:1.5. [S(-)-isomer: Baer & Kates J Am Chem Soc 72 942 1950, Hanahan & Vercamer J Am Chem Soc 7 6 1804 1954, R(+)-isomer: Tattrie et al. Arch Biochem 78 319 1958, Beilstein 2 IV 1173.] The racemate [40290-32-2] is polymorphic with different IR spectra. When crystallised from hexane, or other solvents, the higher melting form with m 71.5-72.5o is obtained. The melt then solidifies to give the lower melting -form with m 49.7-50o. The -form has m 61o (65-66o is also reported). When the lower melting forms are kept at their melting temperatures for a while, they are converted to the higher melting form. [Howe & Malkin J Chem Soc 2663 1951, Baer & Kates J Am Chem Soc 72 942 1950, Beilstein 2 IV 1173.]
1,2-DIPALMITOYL-SN-GLYCEROL Preparation Products And Raw materials
Raw materials
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30334-71-5, 1,2-DIPALMITOYL-SN-GLYCEROLRelated Search:
  • D-ALPHA,BETA-DIPALMITIN
  • DPG
  • L-1,2-DIPALMITOYLGLYCEROL
  • 16:0 DG
  • 1,2-DIPALMITOYL-SN-GLYCEROL
  • 1,2-DIPALMITIN
  • 1,2-DIPALMITOYL-SN-3-GLYCEROL
  • 1,2-DIHEXADECANOYL-SN-GLYCEROL
  • (S)-1,2-DIPALMITIN
  • (S)-GLYCEROL 1,2-DIPALMITATE
  • (S)-1-(hydroxymethyl)ethane-1,2-diyl dipalmitate
  • 1,2-DIPALMITOYL-SN-GLYCEROL (C16:0)
  • (S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat
  • L-1,2-DIPALMITOYLGLYCEROL synthetic
  • Einecs 250-131-4
  • 1,2-Di-O-palMitoyl-sn-glycerol
  • Hexadecanoic Acid 1,1'-[(1S)-1-(HydroxyMethyl)-1,2-ethanediyl] Ester
  • NSC 269964
  • sn-1,2-DipalMitin
  • D-a,b-DipalMitin
  • (S)-1,2-Dipalmitin, (S)-Glycerol 1,2-dipalmitate, 1,2-Dihexadecanoyl-sn-glycerol
  • (-)-L-1,2-Dipalmitin
  • (S)-Propane-1,2,3-triol 1,2-dipalmitate
  • 1-O,2-O-Dipalmitoyl-L-glycerol
  • Bishexadecanoic acid (S)-3-hydroxypropane-1,2-diyl ester
  • Bispalmitic acid (S)-3-hydroxypropane-1,2-diyl ester
  • (-)-1,2-di-O-hexadecanoyl-sn-glycerol
  • DipalMitoyl-sn-glycerol L-0016
  • DG(16:0/16:0/0:0)
  • 1,2-DIPALMITOYL-SN-GLYCEROL, >=99%
  • (S)-3-Hydroxypropane-1,2-diyl dipalmitate
  • 1,2-Dipalmitin-sn-glycerol
  • 30334-71-5
  • Neutral Glycerides
  • Lipids
  • Glycerides
  • Diradylglycerols
  • Biochemicals and Reagents
  • BioChemical
  • Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives
  • Aliphatics
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Protein Kinase Inhibitors and Activators