Description
1,2-Distearoyl-
sn-glycero-3-PC (DSPC) is a phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the
sn-1 and
sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes.
Chemical Properties
solid
Uses
18:0 PC (DSPC) has been used:
- in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts
- in the preparation of liposomes for immobilization studies
- in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery
Definition
ChEBI: A phosphatidylcholine 36:0 in which both phosphatidyl acyl groups are specified as stearoyl (octadecanoyl).
General Description
1,2-distearoyl-
sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons. It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-
sn-glycero-3-phosphatidylcholine (DPPC).
Biochem/physiol Actions
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system. It is majorly used in conventional and stealth liposome preparation for drug delivery studies.
