Description
n-Decyl-β-D-maltoside is a nonionic surfactant that is commonly used to solubilize and stabilize membrane proteins. It has a critical micelle concentration (CMC) value of 1.8 mM and has been used in the expression of functional recombinant GPCRs.
Chemical Properties
White to off-white powder
Uses
Decyl beta-D-maltopyranoside is used in a study to assess α-helical membrane protein crystallization. It has also been used in a study to investigate enantiomer separation of drugs by micellar electrokinetic chromatography. It aids in solubilizing the active cytochrome oxidase from mitochondria.
Definition
ChEBI: A glycoside resulting from attachment of a decyl group to the reducing-end anomeric centre of a beta-maltose molecule.
References
[1] ANDREA MAGGIONI. Expression, solubilisation, and purification of a functional CMP-sialic acid transporter in Pichia pastoris[J]. Protein expression and purification, 2014, 101: Pages 165-171. DOI:
10.1016/j.pep.2014.07.003[2] KAROLA M. SCHLINKMANN . Maximizing Detergent Stability and Functional Expression of a GPCR by Exhaustive Recombination and Evolution[J]. Journal of Molecular Biology, 2012, 422 3: Pages 414-428. DOI:
10.1016/j.jmb.2012.05.039
