Description
Phosphatidic acids can be formed by the acylation of lysophosphatidic acids, the phosphorylation of diacylglycerols, or the removal of the choline group from phosphatidylcholine. They have important roles in intracellular and extracellular signaling. 1,2-
Dipalmitoyl-
sn-
glycero-
3-
phosphate (DPPA) is a phospholipid containing the long-
chain (16:0) palmitic acid inserted at the
sn-
1 and
sn-
2 positions. It is used in the generation of micelles, liposomes, and artificial membranes.
Uses
1,2-Dipalmitoyl-sn-glycero-3-phosphate is a glycerophospholipid used in the characterization of polymer-stabilized liposome system. It is also used in the study of amphotericin B-entrapping lipid nanoparticles and their in vitro and in vivo characteristics.
References
[1] FRANCISCO J SIERRA-VALDEZ. The influence of non polar and polar molecules in mouse motile cells membranes and pure lipid bilayers.[J]. PLoS ONE, 2013: e59364. DOI:
10.1371/journal.pone.0059364[2] WEIGUO JING. Headgroup structure and fatty acid chain length of the acidic phospholipids modulate the interaction of membrane mimetic vesicles with the antimicrobial peptide protegrin-1[J]. Journal of Peptide Science, 2005, 11 11: 735-743. DOI:
10.1002/psc.702
