Description
1,2,3-Tripalmitoyl glycerol is a triacylglycerol that contains palmitic acid at the
sn-1,
sn-2, and
sn-3 positions and has been found in palm oil. It inhibits glucose-stimulated insulin secretion and reduces viability of INS1 cells in a concentration-dependent manner. Myocardial levels of 1,2,3-tripalmitoyl glycerol are elevated by greater than 5-fold in a rat model of diabetes induced by streptozotocin . 1,2,3-Tripalmitoyl glycerol has been used to form the lipid matrices of etoposide-incorporated nanoparticles. Formulations containing 1,2,3-tripalmitoyl glycerol have been used in cosmetic products as thickening and skin-conditioning agents.
Chemical Properties
White, crystalline powder. Soluble in ether and chloroform;
insoluble in water. Combustible.
Uses
Soap, leather dressing.
Uses
Tripalmitin is a triglyceride derived from Palmitic Acid (P144500), a common fatty acid found in plants and animals. Tripalmitin is used in the preparation of solid lipid particles for oral delivery of drugs.
Uses
Glyceryl tripalmitate has been used as a reference standard
- for the generation of calibration curve generation for the quantification of lipids from Azospirillum brasilense
- for the quantification of silk worm embryos and extraembryonic yolk lipids using thin layer chromatography
- for the quantification of triacylglycerol in Neochloris minuta microalgal cells
Definition
ChEBI: A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by palmitic (hexadecanoic) acid.
Biochem/physiol Actions
Glyceryl tripalmitate is a carrier molecule for effective drug delivery and is used solid lipid nanoparticle formulations.
Purification Methods
Crystallise it from acetone, diethyl ether or EtOH. It exists in an -form (m 56.0o), a ’-form (m 63.5o) and a -form (m 65.5o). [Beilstein 2 H 373, 2 I 167, 2 II 340, 2 III 971.]
