Chemical Properties
bright orange powder
Uses
A nitro-aromatic amine with mutagenicity and carcinogenicity
Uses
4-Chloro-2-nitroaniline is used as pharmaceutical intermediate.
Uses
4-Chloro-2-nitroaniline is used
almost exclusively as an intermediate in the synthesis of
pigments.
The greatest potential for human exposure to 4-chloro-2-
nitroaniline is in production and use of pigments made from
the compound.
Preparation
4-Chloro-2-nitrobenzenamine of chlorine.
Production Methods
1,4-Dichloro-2-nitrobenzene is aminated at 165 ℃ by using a process similar to that described for 2- nitroaniline.
General Description
Bright orange powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Chloro-2-nitroaniline forms explosive products on reaction with nitric acid. Can react with oxidizing agents.
Hazard
Toxic by ingestion and inhalation.
Fire Hazard
4-Chloro-2-nitroaniline is probably combustible.
Purification Methods
Crystallise the aniline from hot H2O (m 115.8-116o), EtOH, EtOH/H2O or *C6H6, and dry it for 10hours at 60o in vacuo. It has m 115.5-116o after sublimation. [Beilstein 12 H 729, 12 I 355, 12 II 396, 12 III 1649, 12 IV 1669.]
