Description
Nicosulfuron is a kind of herbicides belonging to the sulfonylurea family. It is a broad-spectrum herbicide that can controls many kinds of maize weeds including both annual weeds and perennial weed including Johnsongrass, quackgrass, foxtails, shattercane, panicums, barnyardgrass, sandbur, pigweed and morningglory. It is a systemic selective herbicide, being effective in killing plants near the maize. This selectivity is achieved through maize’s capability of metabolizing Nicosulfuron into harmless compound. Its mechanism of action is through inhibiting the enzyme acetolactate synthase (ALS) of the weeds, blocking the synthesis of amino acids such as valine and isoleucine, and finally inhibiting the protein synthesis and causing death of weeds.
References
http://www.agchemaccess.com/Nicosulfuron
http://pmep.cce.cornell.edu/profiles/extoxnet/metiram-propoxur/nicosulfuron-ext.html
Chemical Properties
White Solid
Chemical Properties
White crystalline solid or powder. Phenolic
odor.
Uses
Post-emergence sulfonylurea herbicide
Definition
ChEBI: A N-sulfonylurea that is 2-(carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen.
Agricultural Uses
Herbicide: Used as a post-emergence herbicide to control a
variety of weeds on field corn and popcorn crops. Some
formulations may be U.S. EPA restricted Use Pesticides
(RUP). Approved for use in EU countries.
Trade name
ACCENT®; BASIS®; CELEBRITY®;
CHALLENGER®; DASUL®; DPX 79406® Herbicide
(with Rimsulfuron); DPX-V9636®; GHIBLI®; LAMA®;
MATRIX® Herbicide (with Rimsulfuron); MILAGRO®;
MISTRAL®; MOTIVEL®; NISSHIN®; SAMSON®;
STEADFAST® (nicosulfuron + rimsulfuron)
Potential Exposure
Nicosulfuron is a sulfonylurea postemergence
herbicide used to control a variety of weeds on
field corn and popcorn crops. Some formulations may be
registered as United States Restricted Use Pesticides (RUP)
Metabolic pathway
In the four systems investigated, the primary
degradation pathway is to yield pyridine sulfonamide
and 4,6-dimethoxy-2-aminopyrimidine. The plant and its
microsomal system include the hydroxylation pathway
at the 4-position of the pyrimidine ring, resulting in
hydrolysis products by the cleavage of the sulfonylurea
linkage. In mammals, contraction or rearrangement of
the sulfonylurea linkage for nicosulfuron and N-
demethylated nicosulfuron yields two unique products
which have the N-pyridyl-N-pyrimidyl urea moiety and
result in the uracil metabolite.
Shipping
UN3077 or UN3082 Environmentally hazardous
substances, liquid or solid, n.o.s., Hazard Class: 9; Labels:
9-Miscellaneous hazardous material, Technical Name
Required.
Incompatibilities
Slowly hydrolyzes in water, releasing
ammonia and forming acetate salts. Decomposed ＞165℃.
Waste Disposal
It is the responsibility of chemical
waste generators to determine the toxicity and physical
properties and of a discarded chemical and to properly identify
its classification and certification as a hazardous waste and to
determine the disposal method. United States Environmental
Protection Agency guidelines for the classification determination
are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult and follow all regional, national, state
and local hazardous waste laws to ensure complete and accurate
classification and disposal methods.
