ChemicalBook CAS DataBase List D-(-)-Salicin

D-(-)-Salicin

Product NameD-(-)-Salicin
CAS138-52-3
CBNumberCB2349192
MFC13H18O7
MW286.28
EINECS205-331-6
MDL NumberMFCD00006590
MOL File138-52-3.mol
MSDS FileSDS

Chemical Properties

Melting point	196-202 °C
Boiling point	388.65°C (rough estimate)
alpha	-61.5 º (c=5, water)
Density	1.4340
refractive index	-62 ° (C=3, H2O)
storage temp.	2-8°C
solubility	36g/l
form	Fine Crystalline Powder
pka	12.80±0.70(Predicted)
color	White
Water Solubility	36 g/L (15 ºC), 250 g/L (60 ºC)
Merck	14,8324
BRN	89593
Stability	Stable, but light sensitive. Incompatible with strong oxidizing agents.
InChIKey	NGFMICBWJRZIBI-MICYEWLZSA-N
LogP	-1.232 (est)
CAS DataBase Reference	138-52-3(CAS DataBase Reference)
FDA UNII	4649620TBZ
NIST Chemistry Reference	Salicin(138-52-3)
EPA Substance Registry System	.beta.-D-Glucopyranoside, 2-(hydroxymethyl)phenyl (138-52-3)

Safety

Symbol(GHS)

Signal word

Warning

Hazard statements

H317

Precautionary statements

P280-P302+P352

Hazard Codes

Risk Statements

Safety Statements

36/37-37-24/25-36

WGK Germany

RTECS

LZ5901700

3-10

TSCA

Yes

HS Code

29389090

NFPA 704:

	1
2		0

D-(-)-Salicin Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich S0625	5g	$57.1	D-(?)-Salicin ≥99% (GC)	Buy
Sigma-Aldrich 79588	100mg	$230	D-(?)-Salicin analytical standard	Buy
TCI Chemical S0003	5g	$34	Salicin >98.0%(HPLC)	Buy
TCI Chemical S0003	25g	$98	Salicin >98.0%(HPLC)	Buy
Alfa Aesar A16524	5g	$40.2	D-(-)-Salicin, 99%	Buy

D-(-)-Salicin Chemical Properties,Usage,Production

Description

D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities, it can inhibit the LPS-induced inflammation in RAW264.7 cells and mouse models.

Chemical Properties

white crystals or powder

Uses

D-(-)-Salicin has been used:

to study its in vitro anticoagulant and antiplatelet activities
as a standard in high performance liquid chromatography method (HPLC) for quantitation of salicin from willow plant
as a tastant in taste threshold assay
as a constituent of nutrient agar-salicin medium for selective isolation of Lactobacillus paracasei

Uses

Standard substrate in evaluating enzyme Preparations contg b-glucosidase: Weidenhagen, Z. Ver. Zucker-Ind. 79, 591 (1929).

Uses

analgesic, antipyretic

Uses

H1 antihistamine (nonsedating)

Definition

ChEBI: An aryl beta-D-glucoside that is the beta-D-glucoside of the phenolic hydroxy group of salicyl alcohol.

General Description

Salicin is a non-phenolic glucosidic compound extracted from meadowsweet (Filipendula ulmaria L). It is majorly used as a substitute for quinine. Salicin can be used as a therapeutic for patients suffering from rheumatic fever. Salicin acts a metabolic precursor for salicylic acid. It is a novel phytochemical that exhibits immunological cross functions in plants and humans. Salicin facilitates growth and reproduction in plants. In addition, It also protects plants against biotic and abiotic stress.

Biochem/physiol Actions

D-(?)-Salicin exerts anti-rheumatism and anti-inflammatory activities. It inhibits lipopolysaccharide (LPS) induced inflammation in in vitro and in vivo studies. It regulates different signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). It also regulates cytokines concentration such as tumor necrosis factor-alpha(TNF-α), interleukin-1β, interleukin-6, and interleukin-10.

Purification Methods

Crystallise D(-)-salicin from EtOAc, EtOH or water and sublime it at 190-195o/12mm. [Armour et al. J Chem Soc 412 1961, IR: Pearl & Darling J Org Chem 24 731 1959, Beilstein 17 III/IV 2986, 17/7 V 113.]

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	1287	58
Changsha Staherb Natural Ingredients Co., Ltd.	+86-0731-84213302 +86-18374838656	info@staherb.cn	China	1025	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12837	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	5975	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	422	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	2397	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9116	55

D-(-)-Salicin

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