Description
Hydrocortisone 17-butyrate: a new non-fluorinated topical corticosteroid.
Hydrocortisone 17-butyrate could be used in psoriasis, eczema and other inflammatory dermatoses. It may be found in creams, lotions, ointments, and powders and in ear, nose and eye drops for rhinitis, otitis, and conjunctivitis. In double-blind paired comparisons with other topical corticosteroids, the efficacy of hydrocortisone 17-butyrate 0.1% has generally been indistinguishable from that of triamcinolone acetonide 0.1%, fluocinolone acetonide 0.025% or betamethasone 17-valerate 0.1% in patients with eczema or psoriasis. When applied to the face of patients with atrophy superimposed on rosacea and perioral dermatitis resulting from prolonged use of fluorinated topical corticosteroids, hydrocortisone 17-butyrate 0.1% did not prevent the beneficial effect of systemic tetracycline nor the disappearance of telangiectasis and tended to be more effective than hydrocortisone 1%[1].
Uses
Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.
Uses
Hydrocortisone-17-butyrate is a topical corticosteroid with anti-inflammatory properties; marker for topical corticosteroid allergy.
Definition
ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.
brand name
Locoid (Ferndale); Locoid (Yamanouchi).
Biochem/physiol Actions
Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.
Contact allergens
Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti-
sone. It represents the D2 group of corticosteroids, non
C 16 methylated with a C 17 ester: hydrocortisone
17-butyrate, hydrocortisone 17-valerate, hydrocortisone
aceponate (17-propionate and 21-acetate), methylpred-
nisolone aceponate, and prednicarbate. It is sometimes
hydrolyzed in vivo into hydrocortisone, giving allergic
reactions to group-A-sensitized people.
References
[1] R N Brogden. “Hydrocortisone 17-butyrate: a new topical corticosteroid preliminary report.” ACS Chemical Neuroscience 12 4 (1976): 249–57.
