Uses
3,20-Dioxopregn-4-en-17-beta-yl acetate, also known as 17-Hydroxyprogesterone acetate, is a new steroid
for oral administration. It has a progestational activity
which is at least twice that of anhydrohydroxyprogesterone[1].
Mechanism of action
3,20-Dioxopregn-4-en-17-beta-yl acetate could induces secretory changes in the endometrium and luteal changes in the exfoliated vaginal epithelial cells, reduces fern-like patterns of the cervical mucus, causes a rise of basal body temperature, and induces withdrawal bleeding in castrates[1].
References
[1] Davis M, et al. 17-α-HYDROXYPROGESTERONE ACETATE; AN EFFECTIVE PROGESTATIONAL SUBSTANCE ON ORAL ADMINISTRATION. The Journal of clinical endocrinology and metabolism, 1957; 17: 1237–1244,.
