Chemical Properties
Light yellow to yellow clear liquid
Uses
All-
rac-alpha-tocopheryl acetate for peak identification may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.
Uses
Vitamin E (α-tocopherol) occurs naturally in most vegetable oils. The highest concentrations are found in com, soybean oils, sunflower seed, wheat germ, rapeseed, alfalfa, and lettuce. It is claimed to have age-retardant properties. May produce erythemamultiforme-like eruptions. It is used in a number of cosmetic products; creams are used for scars, striae, and bums; in pharmaeeutical ereams and deodorants; as an antioxidant in foods.
Uses
vitamin E acetate (tocopherol acetate) is an anti-oxidant with skinmoisturizing activity. given its free-radical scavenging properties, it is useful in uV protective products. Vitamin e acetate is commonly used to replace vitamin e because it is more stable and is converted to vitamin e by the body.
Uses
anti-Altzheimer therapeutic
Definition
ChEBI: DL-alpha-Tocopherol acetate is a tocol.
General Description
DL-α-Tocopherol acetate is a stable ester form of vitamin E, widely used in the formulation of cosmetics for the prevention or correction of skin damage.
Hazard
A reproductive hazard.
Flammability and Explosibility
Non flammable
Contact allergens
Tocopherol and tocopheryl acetate are used mainly as
antioxidants. Tocopheryl acetate, an ester of tocopherol
(vitamin E), can induce allergic contact dermatitis.
Biochem/physiol Actions
Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by Homosapiens. DL-α-Tocopherol acetate can inhibit oxidation of linoleate.
Purification Methods
It is a viscous liquid which is purified by distillation under high vacuum under N2 or Ar and stored in sealed ampoules in the dark. It is considerably more stable to light and air than the parent unacetylated vitamin. It is insoluble in H2O but freely soluble in organic solvents. All eight stereoisomers have been synthesised. The commercially pure d-tocopheryl acetate (2R,4'R,8'R) has b 180-200o/0.7mm and [] D 20 +3.9o (c 5, EtOH); see above. [Cohen et al. Helv Chim Acta 64 1158 1981, Beilstein 17/4 V 169.]
