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19-Norethindrone acetate

19-Norethindrone acetate Structure
19-Norethindrone acetate
  • CAS No.51-98-9
  • Chemical Name:19-Norethindrone acetate
  • CBNumber:CB9307049
  • Molecular Formula:C22H28O3
  • Formula Weight:340.46
  • MOL File:51-98-9.mol
19-Norethindrone acetate Property
  • Melting point: :161-162°
  • Boiling point: :416.25°C (rough estimate)
  • Density  :1.1236 (rough estimate)
  • refractive index  :-34 ° (C=1, Dioxane)
  • storage temp.  :2-8°C
  • solubility  :Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol.
  • form  :neat
  • color  :Crystals from Me2CO/hexane
  • Water Solubility  :3.162mg/L(10 ºC)
  • Merck  :14,6697
  • InChIKey :IMONTRJLAWHYGT-ZCPXKWAGSA-N
  • CAS DataBase Reference :51-98-9(CAS DataBase Reference)
  • FDA UNII :9S44LIC7OJ
  • Proposition 65 List :Norethisterone Acetate (Norethindrone Acetate)
  • NCI Drug Dictionary :Aygestin
  • NIST Chemistry Reference :Norethindrone acetate(51-98-9)
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :40-48
  • Safety Statements  :36/37
  • WGK Germany  :3
  • RTECS  :RC8965000
  • HS Code  :29372390
  • Toxicity :dlt-mus-orl 1120 mg/kg/4W MUREAV 26,535,74
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H351
  • Precautionary statements P280-P281
19-Norethindrone acetate Price More Price(18)
  • Brand: Sigma-Aldrich
  • Product number: 46527
  • Product name : 19-Norethindrone acetate
  • Purity: VETRANAL
  • Packaging: 100mg
  • Price: $108
  • Updated: 2021/12/16
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  • Brand: Sigma-Aldrich
  • Product number: PHR2534
  • Product name : Norethindrone acetate
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 200MG
  • Price: $129
  • Updated: 2021/12/16
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  • Brand: Sigma-Aldrich
  • Product number: Y0001532
  • Product name : Norethisterone acetate for system suitability
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: N1225000
  • Product name : Norethisterone acetate
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/12/16
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  • Brand: Sigma-Aldrich
  • Product number: BP267
  • Product name : Norethisterone acetate
  • Purity: British Pharmacopoeia (BP) Reference Standard
  • Packaging: 
  • Price: $220
  • Updated: 2021/12/16
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19-Norethindrone acetate Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Originator Norlestrin,Parke Davis ,US,1964
  • Uses Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.
  • Uses Oral contraceptive (in combination with estrogen)
  • Definition ChEBI: A 3-oxo Delta4-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.
  • Manufacturing Process 2.98 grams of 17-ethinyl-19-nor-testosterone (norethindrone) are suspended in 30 cc of acetic anhydride and a solution of 1.9 grams of p-toluenesulfonic acid in 19 cc of acetic anhydride is gradually added while cooling and stirring. Complete dissolution takes place after about one hour. After additional 30 to 60 minutes, a thick, pasty mass separates. The reaction is permitted to continue for a total period of 5 hours, whereupon water is added to the reaction mixture and the 3-enol-17-diacetate which separates after stirring for 1 to 2 hours is filtered off, washed until neutral and dried in vacuo over calcium chloride at room temperature.
    In order to prepare the monoacetate, the crude diacetate is suspended in 150 cc of methanol and, after adding 1.5 cc, concentrated hydrochloric acid, heated to boiling for 15 minutes in a nitrogen atmosphere. The crude monoacetate which separates upon the addition of water after cooling is filtered off, washed and dried in vacuo over calcium chloride at room temperature. The pure 17-acetete, obtained after repeated recrystallizations from methylene chloride/hexane has a MP of 161° to 162°C.
  • brand name Aygestin (Duramed); Norlutate (Parke-Davis).
  • Therapeutic Function Chemical Name: 19-Nor-17α-pregn-4-en-20-yn-3one, 17-hydroxy-, acetate
  • General Description
    Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
  • Safety Profile Suspected carcinogen with experimental tumorigenic data. Human reproductive effects by ingestion and implant routes: menstrual cycle changes, postpartum effects, and changes in fertility. A human teratogen by an unspecified route with developmental abnormalities of the urogenital system. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in the treatment of menstrual dsorders and uterine bleedmg.
19-Norethindrone acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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51-98-9, 19-Norethindrone acetateRelated Search:
  • SH-420C
  • 4-ESTREN-17ALPHA-ETHYNYL-17BETA-OL-3-ONE 17-ACETATE
  • 4-ESTREN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE ACETATE
  • ACETIC ACID 17-ETHYNYL-13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPE
  • 19-NORETHISTERONE 17-ACETATE MIN. 98 % (
  • NORETHISTERONE ACETATE, EP STANDARD
  • NORETHISTERONE ACETATE, IMP. A (EP): NORETHISTERONE MM(CRM STANDARD)
  • NORETHISTERONE ACETATE, WHO STANDARD
  • NORETHISTERONE ACETATE, IMP. G (EP): 6-KETONORETHISTERONE ACETATE, MM(CRM STANDARD)
  • NORETHISTERONE ACETATE 98+%
  • NORETHINDRONE ACETATE CRYSTALLINE
  • NORETHISTERONE ACETATE, IMP. F (EP): 6-HYDROXYNORETHISTERONE ACETATE, MM(CRM STANDARD)
  • NORETHISTERONE ACETATE, USP STANDARD
  • NORETHISTERONE ACETATE, IMP. B (EP): 3-OXO-19-NOR-17ALPHA-PREGN-5(10-EN-20YN-17YL ACETATE MM(CRM STANDARD)
  • NORETHISTERONE ACETATE, MM(CRM STANDARD)
  • NorethisteroneAcetateBp93
  • 17-Hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one acetate
  • 17α-ethynyl-17β-hydroxy-19-nor-4-androsten-3-one 17-acetate
  • 19-NOR-17ALPHA-ETHYNYLTESTOSTERONE ACETATE
  • 19-NORESTHISTERONE ACETATE
  • 19-NORETHINDRONE ACETATE
  • 19-NORETHISTERONE 17-ACETATE
  • 19-NORETHISTERONE ACETATE
  • 17a-ethynyl-19-nortestosterone 17b-acetate
  • 17ALPHA-ETHYNYL-17BETA-HYDROXY-19-NOR-4-ANDROSTEN-3-ONE 17-ACETATE
  • 17ALPHA-ETHYNYL-19-NORTESTOSTERONE ACETATE
  • 17ALPHA-ETHYNYL-19-NORTESTOSTERONE 17BETA-ACETATE
  • 17-hydroxy-19-nor-17a-4-pregnen-20-yn-3-one acetate
  • 17-HYDROXY-19-NOR-17ALPHA-4-PREGNEN-20-YN-3-ONE ACETATE
  • Norethisterone acetate for system suitability
  • NORETHINDRONE ACETATE
  • NORETHISTERONE ACETATE
  • acetic acid (17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl) ester
  • 17-acetyloxy(17-alpha)-19-norpregn-4-estren-17-beta-ol-acetate-3-one
  • 17-Acetyloxy(17alpha)-19-norpregn-4-estren-17beta-ol-acetate-3-one
  • 17alpha-Ethinyl-19-nortestosterone 17beta-acetate
  • 17alpha-Ethinyl-19-nortestosterone acetate
  • 17-alpha-ethinyl-19-nortestosterone-17-beta-acetate
  • 17-alpha-ethinyl-19-nortestosteroneacetate
  • 17-alpha-ethynyl-17-beta-acetoxy-19-norandrost-4-en-3-one
  • 17alpha-Ethynyl-17beta-acetoxy-19-norandrost-4-en-3-one
  • 17alpha-Ethynyl-17-hydroxyestr-4-en-3-one acetate
  • 17-alpha-ethynyl-17-hydroxyestr-4-en-3-oneacetate
  • 17-beta-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one
  • 17beta-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one
  • 17beta-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one acetate
  • (17-alpha)-17-(Acetyloxy)-19-norpregn-4-en-20-yn-3-one
  • (17α)-17-(acetyloxy)-19-norpregn-4-en-20-yn-3-one
  • 17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-on
  • 17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one
  • 17-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one
  • 17-beta-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-oneacetate
  • 17beta-Hydroxy-19-norpregn-4-en-20-yn-3-one acetate
  • 17-Ent
  • 17-Ethynyl-3-oxoestr-4-en-17-yl acetate
  • 17-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one acetate
  • 17-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-oneacetate
  • 17-Acetyloxy-17-ethinylestr-4-en-3-one