Description
Calcium gluconate is the calcium salt of gluconate, being an oxidative product of glucose containing 9.3% calcium. Calcium gluconate is a kind of mineral supplement and medication. It can be used for vein injection to treat the low blood calcium, high blood potassium, and magnesium toxicity. It is required only when there is not enough calcium in the diet. It is also used for the treatment of black widow spider bites to relieve muscle cramping and treatment of osteoporosis or rickets. It can also be used to decrease the capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses.
References
http://www.drugbank.ca/drugs/DB11126
https://en.wikipedia.org/wiki/Calcium_gluconate
Chemical Properties
white crystalline powder or granules
Uses
Calcium Gluconate is used as an inert ingredient in pesticide formulations applied to crops. It is also used as a supplement to fortify beverages and foods lacking a sufficient amount of calcium.
Uses
In sewage purification; in coffee powders to prevent caking.
Uses
analgesic, antipyretic
Uses
Calcium Gluconate is a white crystalline granule or powder that
functions as a firming agent, formulation aid, sequestrant, and sta-
bilizer. at room temperature the anhydrous form has a solubility of
approximately 1 g in 30 ml of water, which improves in boiling
water to approximately 1 g in 5 ml of water. it also exists as calcium
gluconate (monohydrate). it is used as a source of calcium ions for
sodium alginate gels, and as a calcium fortifier in baked goods, pud-
dings, and dairy product analogs. it functions as a coagulation aid
in milk and instant pudding powders and as a means of masking the
bitter aftertaste of some artificial sweeteners.
Definition
ChEBI: Calcium gluconate is the calcium salt of D-gluconic acid. It has a role as a nutraceutical. It contains a D-gluconate.
brand name
Calglucon (Novartis).
Flammability and Explosibility
Non flammable
Industrial uses
calcium gluconate [Ca(C
6H
11O
7)
2] is used as a
food additive in vitamin pills.injection of a 10% calcium gluconate has been recommended. It has to be kept
in mind that the plasma Ca
2+ level and any changes to the electrocardiogram (ECG) have to be carefully
monitored.
Clinical Use
Hypocalcaemia
Safety Profile
Moderately toxic by
subcutaneous, intraperitoneal, and
intravenous routes. Human systemic effects
in infants by intramuscular route: dermatitis
and fever. When heated to decomposition it
emits acrid smoke and fumes. See also
CALCIUM COMPOUNDS.
Veterinary Drugs and Treatments
Calcium salts are used for the prevention or treatment of hypocalcemic
conditions.
Drug interactions
Potentially hazardous interactions with other drugs
Can impair absorption of some drugs, e.g. iron,
ciprofloxacin.
Metabolism
Calcium is absorbed mainly from the small intestine by
active transport and passive diffusion. About one-third
of ingested calcium is absorbed although this can vary
depending upon dietary factors and the state of the small
intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a
metabolite of vitamin D, enhances the active phase of
absorption.
Excess calcium is mainly excreted renally. Unabsorbed
calcium is eliminated in the faeces, together with that
secreted in the bile and pancreatic juice. Minor amounts
are lost in the sweat, skin, hair, and nails.
Purification Methods
Dissolve it in H2O, filter and precipitate it by adding MeOH. Filter off the solid and dry it in a vacuum at 85o. Alternatively, dissolve it in H2O, filter (from insoluble inorganic Ca) and evaporate it to dryness under vacuum at 85o. [March et al. J Am Pharm Assoc 41 366 1952, Beilstein 3 IV 1255.]
