Description
Prazosin Hcl, a quinazoline derivative, is the first of a new chemical class of antihypertensives.
Physical properties
Prazosin Hcl is a white, crystalline substance, slightly soluble in water and isotonic saline, and has a molecular weight of 419.87.
Uses
Prazosin Hcl is indicated for the treatment of hypertension, to lower blood pressure. It can be used alone or in combination with other antihypertensive drugs such as diuretics or beta-adrenergic blocking agents.
Brand name
Minipress (Pfizer)
Biological Activity
α 1 and α 2B -adrenoceptor antagonist. Also a potent antagonist at the melatonin MT 3 receptor (K i = 10.2 nM). Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .
Biochem/physiol Actions
Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin Hcl can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.
Side effects
Headache, drowsiness, tiredness, weakness, blurred vision, nausea, vomiting, diarrhea, or constipation
