Pinacidil

Bezeichnung:Pinacidil

CAS-Nr85371-64-8

Englisch Name:Pinacidil

CBNumberCB9498330

SummenformelC13H21N5O

Molgewicht263.35

MOL-Datei85371-64-8.mol

Pinacidil physikalisch-chemischer Eigenschaften

Schmelzpunkt	164-165°
storage temp.	RT
Löslichkeit	ethanol: 14 mg/mL
Aggregatzustand	solid
pka	pKa 空 (Uncertain)
Farbe	white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS Datenbank	85371-64-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	36
WGK Germany	3
Toxizität	LD50 in mice, rats (mg/kg): 600, 570 orally (Petersen, 1978)

Gefahreninformationscode (GHS)

Pinacidil Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Pinacidil is a peripheral vasodilator useful in the management of arterial hypertension of all degrees of seventy, usually in combination with a diuretic or beta-blocker. Preclinical evidence suggests that its hypotensive effect may be attributed to potassium channel activation.
Originator
Leo (Denmark)
Verwenden
Pinacidil monohydrate has been used:
- in repolarization studies by infusing into left anterior descending artery (LAD)
- to induce ATP-sensitive K⁺ (K_ATP) current in ventricular myocytes for electrophysiological studies
- as a KATP opener to treat myocardial cells
Verwenden
cardiac stimulant
Verwenden
Pinacidil Monohydrate is a K+ channel opener, used to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. Vasodilator. Antihypertensive agent.
Definition
ChEBI: Pinacidil is an organic molecular entity.
Trademarks
Pindac (Leo).
Biochem/physiol Actions
Pinacidil is a KATP channel agonist. It protects cardiomyocytes by preventing loss of mitochondrial membrane potential. It prevents the caspase 3 activation in hypoxia/reoxygenation injury.
Einzelnachweise
1) Hermsmeyer et al. (1988), Pinacidil actions on ion channels in vascular muscle; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S17 2) Gollasch et al. (1995), Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells; J. Pharmacol. Exp. Therap., 275 681 3) Cohen & Kurz (1988), Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S5 4) Teshima et al. (2003), Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress; Stroke, 34 1796 5) Xie et al. (2010), K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS protection; J. Neurosci. Res., 88 428 6) Zhang et al. (2008), Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats; Neurosci. Bull., 24 7

Pinacidil Upstream-Materialien And Downstream Produkte

Pinacidil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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