Piribedil

Bezeichnung:Piribedil

CAS-Nr3605-01-4

Englisch Name:2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

CBNumberCB6261328

SummenformelC16H18N4O2

Molgewicht298.34

MOL-Datei3605-01-4.mol

Synonyma

Piribedil

Piribedil physikalisch-chemischer Eigenschaften

Schmelzpunkt	98°
Siedepunkt	439.76°C (rough estimate)
Dichte	1.1183 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	7.17±0.10(Predicted)
Aggregatzustand	Solid
Farbe	White
Merck	14,7493
CAS Datenbank	3605-01-4(CAS DataBase Reference)

Sicherheit

RTECS-Nr.	UV9704000
HS Code	2933.59.8000
Toxizität	LD50 in mice (mg/kg): 88 i.v., 690 i.p., 1460 orally (Laubie)

Gefahreninformationscode (GHS)

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Solid
Originator
Trivastal, Eutherapie ,France,1969
Verwenden
Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.
Verwenden
Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impai rment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.
Definition
ChEBI: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.
Manufacturing Process
To a solution of 21 g of 1-(3':4'-methylenedioxybenzyl)-piperazine in solution in 300 cc of anhydrous xylene there were added 28 g of anhydrous potassium carbonate and then 11.3 g of 2-chloropyrimidine. The suspension was then heated for 9 hours at boiling point (130°C). After this time, the mixture was cooled and extracted several times with 10% hydrochloric acid. The acid solution obtained was washed with ether and then rendered alkaline with potassium carbonate; the oily product which was separated was extracted with chloroform and this, after drying with potassium carbonate and evaporation, gave an oily residue weighing 20 g. By dissolution in boiling ethanol and crystallization, 15 g of crystals melting at 96°C were recovered.
Therapeutic Function
Vasodilator

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Upstream-Materialien And Downstream Produkte

Piribedil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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