Eosin

Bezeichnung:Eosin

CAS-Nr17372-87-1

Englisch Name:EOSIN

CBNumberCB9461211

SummenformelC20H6Br4Na2O5

Molgewicht691.85418

MOL-Datei17372-87-1.mol

Synonyma

Dinatrium-2-(2,4,5,7-tetrabrom-6-oxido-3-oxoxanthen-9-yl)benzoat

Eosin

Eosin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300°C
Dichte	1.02 g/mL at 20 °C
Dampfdruck	0Pa at 25℃
Flammpunkt	11 °C
storage temp.	Store at RT.
Löslichkeit	H₂O: 0.1 g/mL, dark red
Colour Index	45380
Aggregatzustand	Solid
pka	2.9, 4.5(at 25℃)
Farbe	Reddish
Säure-Base-Indikators(pH-Indikatoren)	0(yellow)-3(green fluoresc.)
PH	9.2 (10g/l, H2O, 20℃)
Wasserlöslichkeit	freely soluble
maximale Wellenlänge (λmax)	514nm
Merck	14,3603
BRN	3586809
Stabilität	Stable. Incompatible with strong oxidizing agents.
Biologische Anwendungen	Treating age-related macular degeneration,burns,cancer,diabetes,obesity,dental bone defects,gastroesophageal reflux disease,prostate cancer,viral diseases; stents; wound-healing materials
Major Application	Photovoltaic devices, color filter, nanoscale host material, detection of latent fingerprints, inks, detergents, hair dyes, cosmetics, implantable drug delivery devices, stents, diagnosis of breast lesions, labeling nucleic acids, detecting proteins, stress biomarkers, phosphoprotein, breast cancer metastases, antimicrobial agent, treatment of burns, endodontic, diabetes, obesity, cancer, radiochemotherapy, DNA sequencing, gene expression profiling, wound healing promoters
LogP	-1.33
CAS Datenbank	17372-87-1(CAS DataBase Reference)
EPA chemische Informationen	Eosin Yellowish (YS) (17372-87-1)

Sicherheit

Kennzeichnung gefährlicher	F,T,Xn,Xi
R-Sätze:	11-23/24/25-39/23/24/25-52/53-41-22-36-10
S-Sätze:	7-16-36/37-45-24/25-61-39-26
RIDADR	UN 1230 3/PG 2
WGK Germany	1
RTECS-Nr.	LM5850000
TSCA	Yes
HS Code	32041200
Toxizität	LD50 orally in Rabbit: > 2000 mg/kg

Gefahreninformationscode (GHS)

EOSIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R41:Gefahr ernster Augenschäden.
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
R10:Entzündlich.
S-Sätze Betriebsanweisung:
S7:Behälter dicht geschlossen halten.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S39:Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
brownish-red powder
Verwenden
Eosin is most often used as a counterstain to haematoxylin in H&E (haematoxylin and eosin) staining. H&E staining is one of the most commonly used techniques in histology.
Verwenden
Anti Septic
Verwenden
Eosin Yellowish noted to reduce the affinity of Mg2+-ATPase for ATP and increase the enzyme affinity for Mg2+ at concentrations of 10-50 ?M. At higher concentrations near 100 ?M the affinity for Mg2+-ATPase for the ion-activator has been shown to be reduced. This compound has also been reported to be a photosensitizer that works as a molecular photoelectrode via catalyzation of the visible-light-driven electron-transfer reaction. Eosin Y is also used to stain structures such as muscle, cytoplasm, and collagen. This agent also enhances fluorescent quenching abilities by forming a complex with polyvinulpyrrolidone.
synthetische
countries called red. Fluorescent element (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromine into four bromine derivatives, and then into sodium salt.
Definition
ChEBI: An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.
Flammability and Explosibility
Not classified
Biologische Aktivität
ami5/eosin y disodium salt is a non-selective protein methyltransferase inhibitor.post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. the enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription.
Sicherheitsprofil
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of Brand NazO. See also BROMIDES.
in vitro
ami5/eosin y disodium salt has been identified as a competitive inhibitor of sam binding and had been shown to inhibit not only prmts but also lysine methylation by the set7 and disruptor of telomeric silencing 1-like (dot1l) mtases in vitro. both ami5/eosin y disodium salt and its analog ami-1 have been used as lead compounds for the development of novel mtase-specific inhibitors. moreover, it was found that ami5/eosin y disodium salt could inhibit set7 in vitro and decrease h3k4m1 in vascular endothelial cells. [1].
IC 50
0.78 and 1.41 μm for hmt1p and prmt1, respectively
Lager
+4°C
läuterung methode
Dissolve it in the minimum volume of H2O (1g/mL), filter and add EtOH until separation of salt is complete. Filter the solid off, wash it with absolute EtOH, then Et2O and dry it first in air, then at 100o. It is used for staining blood cells and for estimating traces of Ag. [Selsted & Becker Anal Biochem 155 270 1986, El-Ghamry & Frei Anal Chem 40 1986 1968.] [Beilstein 19 III/IV 2917.] [See above]

Properties and Applications

yellow peach. Orange powder, soluble in water and ethanol with fluorescent blue light is yellowish red solution. Meet strong sulfuric acid yellow, it will be diluted yellow light red precipitate generated. Dyeing copper ions in the blue colour and lustre; Iron ion colour and lustre in the dark blue. Discharge the gender is good. Mainly used in red ink and red pencils, only comfortable carpet dyeing. After refining can be used as medicine and cosmetics of coloring. Can also be used in leather dyeing. The aluminum salt can be used as organic pigments.

Standard	Light Fastness	Soaping		Persperation Fastness	Oxygen bleaching		Fastness to seawater
Standard	Light Fastness	Fading	Stain	Persperation Fastness	Fading	Stain	Fading	Stain
ISO	2	3	3	2	1	2	2	2
AATCC	1	2	2	3	Einzelnachweise [1] okabe j,fernandez az,ziemann m,keating st,balcerczyk a,el-osta a. endothelial transcriptome in response to pharmacological methyltransferase inhibition. chemmedchem.2014 aug;9(8):1755-62. EOSIN Upstream-Materialien And Downstream Produkte Upstream-Materialien Dinatrium-2-(3-oxo-6-oxidoxanthen-9-yl)benzoat Downstream Produkte EOSIN METHYLENE-BLUE ETHYL EOSIN Eosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler. Global(388)Suppliers Region Austria 1 Belgium 1 Canada 2 China 258 Europe 4 France 1 Germany 9 India 46 Japan 5 South Korea 2 Switzerland 4 United Kingdom 6 United States 49 Clear All Done Henan Bao Enluo International TradeCo.，LTD Telefon +86-17331933971<br/>+86-17331933971 E-Mail deasea125996@gmail.com Hebei Jingbo New Material Technology Co., Ltd Telefon +8619931165850 E-Mail hbjbtech@163.com Hebei Saisier Technology Co., LTD Telefon +86-18400010335<br/>+86-13102810335 E-Mail admin@hbsaisier.cn Henan Tianfu Chemical Co.,Ltd. Telefon +86-0371-55170693<br/>+86-19937530512 E-Mail info@tianfuchem.com career henan chemical co Telefon +86-0371-86658258 E-Mail sales@coreychem.com Hubei Jusheng Technology Co.,Ltd. Telefon 18871490254 E-Mail linda@hubeijusheng.com Accela ChemBio Inc. Telefon (+1)-858-699-3322 E-Mail info@accelachem.com Shandong chuangyingchemical Co., Ltd. Telefon 18853181302 E-Mail sale@chuangyingchem.com Chongqing Chemdad Co., Ltd Telefon +86-023-61398051<br/>+8613650506873 E-Mail sales@chemdad.com Shenyang Simchoice Chemical Co.,Ltd Telefon +86-024-23769576<br/>+86-15040101888 E-Mail sales@simchoicechem.com 1of2 17372-87-1, EOSIN Verwandte Suche: Zitronensure Hydrogen-3,6-bis(diethylamino)-9-(2,4-disulfonatophenyl)xanthylium, Natriumsalz Stearinsure Benzylbenzoat Folsure Methanol Natriumbenzoat Tetrahydrofuran Denatoniumbenzoat FURFURYL ALCOHOL RESIN Styrene-acrylic latex Furazolidon Fluorescein 2-(4,5-Dibrom-3,6-dihydroxy-2,7-dinitroxanthen-9-yl)-benzoesure, dinatriumsalz 3',6'-Dihydroxy-5(oder 6)-isothiocyanatospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-on Dinatrium-2-(3-oxo-6-oxidoxanthen-9-yl)benzoat N,N'-1,2-Ethandiylbis(N-(carboxymethyl)glycin,Dinatrium-Salz Emamectin benzoate 1of4 Send Inquriy Website-Startseite\| CAS\| Die PC-Version Chemical Book

Eosin

Gefahreninformationscode (GHS)

EOSIN Chemische Eigenschaften,Einsatz,Produktion Methoden

EOSIN Upstream-Materialien And Downstream Produkte

Eosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

17372-87-1, EOSIN Verwandte Suche: