Furazolidon Produkt Beschreibung

Furazolidone Struktur
67-45-8
  • CAS-Nr.67-45-8
  • Bezeichnung:Furazolidon
  • Englisch Name:Furazolidone
  • Synonyma:Furazolidon
    Furox;Neftin;NF 180;nf-180;Furall;Nicolen;Nifuran;Optazol;Ortazol;Puradin
  • CBNumber:CB8452405
  • Summenformel:C8H7N3O5
  • Molgewicht:225.16
  • MOL-Datei:67-45-8.mol
Furazolidon physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :254-256°C (dec.)
  • Siedepunkt: :366.66°C (rough estimate)
  • Dichte :1.5406 (rough estimate)
  • Brechungsindex :1.7180 (estimate)
  • Flammpunkt: :2 °C
  • storage temp.  : 0-6°C
  • Löslichkeit :formic acid: soluble50mg/mL
  • Aggregatzustand :powder
  • Farbe :yellow
  • Sensitive  :Light Sensitive
  • maximale Wellenlänge (λmax) :365nm(DMSO)(lit.)
  • Merck  :14,4300
  • BRN  :8317414
  • Stabilität: :Stable. Combustible. Incompatible with strong oxidizing agents.
  • InChIKey :PLHJDBGFXBMTGZ-UITAMQMPSA-N
  • NIST chemische Informationen :Furazolidone(67-45-8)
  • EPA chemische Informationen :2-Oxazolidinone, 3-[[(5-nitro-2-furanyl)methylene] amino]-(67-45-8)
Sicherheit

Furazolidone Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
    R40:Verdacht auf krebserzeugende Wirkung.
  • S-Sätze Betriebsanweisung: S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S22:Staub nicht einatmen.
  • Chemische Eigenschaften solid
  • Verwenden Antimicrobial.
  • Verwenden Antiprotozoal; antibacterial
  • Definition ChEBI: A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is us d in the treatment of giardiasis and cholera.
  • Trademarks Benilen;B-fsudi;Carbopuradin;Dapecfuran;Dectolin;Dialidene;Diarexin;Diarin;Diclofur;Doreplston;Dushel;Enterar;Enteroxon;Framenterol;Ft 15;Furaberin;Furacol l.;Furalatin p.;Furalidan;Furaliqua;Furoxona-cp;Fuvitan;Fuxol;Fuzatyl;Galacid;Gamafur s.;Giarlin;Ginvel;Injecur;Intefuran;Kalpec-f;Lacolysat;Mastisept;Multi-med 2;Multi-med 3;Multi-med 6;Neforox alpha cpto;Neftivit;Nicolen r;Nifulin;Parkestress forte;Saleton;Scantrimon;Sibren;Sirben;Syralbuna;Tetrafur;Tranatogen-ova;Ufa-cfo-400;Uterojekt;Vagifurona;Vetoprim;Vsf-medical g 15.
  • Weltgesundheitsorganisation (WHO) Furazolidone, a nitrofuran derivative with antibacterial and antiprotozoal activity, was introduced in 1954. In the 1970s it was shown to have a carcinogenic potential following long-term administration to experimental animals. However, the relevance of this to short-term therapy in man has not been established. The risk-benefit assessment varies and furazolidone remains widely available in many countries for the treatment of diarrhoea and enteritis.
  • Antimicrobial activity It is active against a wide range of enteric pathogens, including Salmonella enterica, Shigella spp., enterotoxigenic Escherichia coli, Campylobacter jejuni, Aeromonas hydrophila, Plesiomonas shigelloides, Vibrio cholerae and V. parahaemolyticus. Yersinia enterocolitica is intrinsically resistant. Furazolidone is also active against the protozoa Giardia lamblia and Trichomonas vaginalis.
  • Acquired resistance Acquired resistance has been observed in V. cholerae O1 and O139, S. enterica serotypes Typhi and Enteritidis, A. hydrophila and Shigella spp. Such resistance may be transferable, and there is cross-resistance with nitrofurantoin. Many of these reports come from the Indian subcontinent, where furazolidone is used widely for treating diarrheal diseases.
  • Hazard A questionable carcinogen, use has been restricted.
  • Pharmazeutische Anwendungen A non-ionic synthetic compound, available for oral use only. It is poorly soluble in water (40 mg/L) and ethanol (90 mg/L), but dissolves well in dimethylformamide (10 g/L). It decomposes in the presence of alkali.
  • Kontakt-Allergie Furazolidone belongs to the group of nitrofurans. This antimicrobial (antibacterial and antiprotozoal) agent is used in veterinary medicine both topically and orally, particularly in animal feed. Reactions are reported in workers exposed to it in animal feeds. Cross-reactions with other nitrofuran derivatives are rare.
  • Pharmakokinetik There is substantial absorption (65–70%) after oral administration, but the drug is heavily metabolized, so that only about 5% of the material excreted is microbiologically active. A dose of 5 mg/kg achieves a maximum plasma concentration of around 1 mg/L. Protein binding is about 30%. Intact drug can be found in various body fluids in concentrations approximating to the minimum inhibitory concentration (MIC) for various intestinal pathogens. Less than 1% of the drug is excreted into urine.
  • Clinical Use Furazolidone is used in gastrointestinal infections and vaginitis. It is mainly used in developing countries to treat diarrheal diseases of varying etiology, but it is not the drug of choice if a specific pathogen has been identified. Use as a secondline agent in giardiasis and as part of multidrug regimens in Helicobacter infection has been advocated.
  • Clinical Use 3-[(5-Nitrofurylidene)amino]-2-oxazolidinone (Furoxone)occurs as a yellow crystalline powder with a bitter aftertaste.It is insoluble in water or alcohol. Furazolidone hasbactericidal activity against a relatively broad range of intestinalpathogens, including S. aureus, E. coli, Salmonella,Shigella, Proteus spp., Enterobacter, and Vibrio cholerae.It is also active against the protozoan Giardia lamblia. It isrecommended for the oral treatment of bacterial or protozoaldiarrhea caused by susceptible organisms. The usualadult dosage is 100 mg 4 times daily.
    Only a small fraction of an orally administered dose of furazolidoneis absorbed. Approximately 5% of the oral dose isdetectable in the urine in the form of several metabolites.Some gastrointestinal distress has been reported with its use.Alcohol should be avoided when furazolidone is being usedbecause the drug can inhibit aldehyde dehydrogenase.
  • Nebenwirkungen Most reported side effects are mild and only rarely cause discontinuation of treatment. Nausea and vomiting are experienced by around 8% of patients. Other adverse events include neurological reactions (mainly headache; 1.3% of patients), ‘systemic’ reactions such as fever and malaise (0.6%) and skin rashes (0.54%). Administration of furazolidone may give rise to inhibition of monoamine oxidase, and disulfiram-like reactions have been reported.
  • Sicherheitsprofil Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: dyspnea, respiratory depression, and eosinophilta. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx.
  • Veterinary Drugs and Treatments Furazolidone is usually a drug of second choice in small animals to treat enteric infections caused by the organisms listed below. Because it is no longer commercially available (in the USA), it may be difficult to locate.
Furazolidone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Furazolidon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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67-45-8, Furazolidone Verwandte Suche:
  • FURAZOLIDONE BP / USP
  • FURAZOLIDONE BP 98
  • foroxone
  • 3-(5-Nitrofurfurylideneamino)-2-oxazolidione
  • FURAZOLIDONE VETRANAL, 250 MG
  • Furazolidone,98%
  • FURAZOLIDONE,USP
  • 3-(5-NITROFURFURYLIDENEAMINO)OXAZOLIDIN-2-ONE(FURAZOLIDONE)
  • N-(5-NITRO-2-FURFURYLIDENE)-3-AMINO-2-OXAZOLIDIN-2-ONE
  • FURAZIDIN(FURAGIN)
  • 3-(5-Nitrofurfurylideneamino)oxazolidin-2-one
  • Furanzolidone
  • 3-(5-Nitrofurfurylideneamino)-4,5-dihydrooxazol-2(3H)-one
  • 3-[[(5-Nitrofuran-2-yl)methylene]amino]oxazolidin-2-one
  • 3-[[(5-Nitrofuran-2-yl)methylene]amino]oxazolidine-2-one
  • Furazolidone,3-(5-Nitrofurfurylideneamino)-2-oxazolidinone
  • Furazolidone (200 mg)
  • 1-(furan-2-yl)pyrrolidin-2-one
  • Furazolldone
  • 3-((5-nitrofurfurylidene)amino)-2-oxazolidinon
  • 3-((5-Nitrofurfurylidene)amino)-2-oxazolidone
  • 3-((5-Nitrofurylidene)amino)-2-oxazolidone
  • 3-([(E)-(5-Nitro-2-furyl)methylidene]amino)-1,3-oxazolidin-2-one
  • Furazolidone solution,100ppm
  • Furazolidone Vetec(TM) reagent grade
  • FurazolidoneUSP, 97-103% (Assay)
  • nf180custommixten
  • Nicolen
  • Nifulidone
  • Nifuran
  • Nifurazolidone
  • Nitrofurazolidone
  • Nitrofurazolidonum
  • Nitrofuroxon
  • Optazol
  • Ortazol
  • Puradin
  • Roptazol
  • Sclaventerol
  • Tikofuran
  • Topazone
  • Trichofuron
  • Tricofuron
  • Tricoron
  • Trifurox
  • USAF ea-1
  • usafea-1
  • Viofuragyn
  • 3-(5-NITROFURFURYLIDENEAMINO)-2-OXAZOLIDINONE
  • 3-(5-NITROFURYLIDENEAMINO)-2-OXAZOLIDINONE
  • LABOTEST-BB LT00244769
  • FURAZOLIDONE
  • FURAZOLIDONUM
  • 3-(5’-nitrofurfuralamino)-2-oxazolidone
  • 3-(5'-Nitrofurfuralamino)-2-oxazolidone
  • 3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinon
  • 3-[[(5-nitro-2-furanyl)methylene]amino]-2-Oxazolidinone
  • 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine