N,N'-1,2-Ethandiylbis(N-(carboxymethyl)glycin,Dinatrium-Salz Produkt Beschreibung

Ethylenediaminetetraacetic acid disodium salt Struktur
139-33-3
  • CAS-Nr.139-33-3
  • Bezeichnung:N,N'-1,2-Ethandiylbis(N-(carboxymethyl)glycin,Dinatrium-Salz
  • Englisch Name:Ethylenediaminetetraacetic acid disodium salt
  • Synonyma:Dinatriumdihydrogenethylendiamintetraacetat;N,N'-1,2-Ethandiylbis(N-(carboxymethyl)glycin,Dinatrium-Salz
    ETA;EDNRA;Gpcr10;hET-AR;4C EDTA;EDTA-2NA;EDTA NA2;Disotate;trilonbd;RATENDOR
  • CBNumber:CB8371263
  • Summenformel:C10H14N2Na2O8
  • Molgewicht:336.21
  • MOL-Datei:139-33-3.mol
N,N'-1,2-Ethandiylbis(N-(carboxymethyl)glycin,Dinatrium-Salz physikalisch-chemischer Eigenschaften
Sicherheit

Ethylenediaminetetraacetic acid disodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/38:Reizt die Augen und die Haut.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R22:Gesundheitsschädlich beim Verschlucken.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  • Chemische Eigenschaften Disodium edetate occurs as a white crystalline, odorless powder with a slightly acidic taste.
  • Chemische Eigenschaften white crystalline solid
  • Verwenden Chelating agent (metal); pharmaceutic aid (chelating agent).
  • Verwenden disodium EDTA is a preservative used in concentrations of 0.1 to 0.5 percent.
  • Verwenden Disodium Dihydrogen EDTA is a sequestrant and chelating agent whose complete name is disodium ethylenediamine tetraacetate. it is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels. A 1% solution has a ph of 4.3–4.7. It is used to control the reaction of trace metals to include calcium and magnesium with other organic and inorganic components in food to prevent deterioration of color, texture, and development of precipitates and to prevent oxidation. Its function is comparable to that of disodium calcium edta.
  • Definition ChEBI: An organic sodium salt that is the anhydrous form of the disodium salt of ethylenediaminetetraacetic acid (EDTA).
  • Vorbereitung Methode Disodium edetate may be prepared by the reaction of edetic acid and sodium hydroxide.
  • Trademarks Endrate (Hospira); Sodium Versenate (3M Pharmaceuticals).
  • Pharmazeutische Anwendungen Disodium edetate is used as a chelating agent in a wide range of pharmaceutical preparations, including mouthwashes, ophthalmic preparations, and topical preparations, typically at concentrations between 0.005 and 0.1% w/v.
    Disodium edetate forms stable water-soluble complexes (chelates) with alkaline earth and heavy-metal ions. The chelated form has few of the properties of the free ion, and for this reason chelating agents are often described as ‘removing’ ions from solution, a process known as sequestering. The stability of the metal–edetate complex is dependent on the metal ion involved and the pH.
    Disodium edetate is also used as a water softener as it will chelate calcium and magnesium ions present in hard water. It is also used therapeutically as an anticoagulant as it will chelate calcium and prevent the coagulation of blood in vitro. Concentrations of 0.1% w/v are used in small volumes for hematological testing and 0.3% w/v in transfusions.
  • Sicherheitsprofil Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. The calcium disodium salt of EDTA is used as a chelating agent in treating lead poisoning. When heated to decomposition it emits toxic fumes of NOx and NasO.
  • Sicherheit(Safety) Disodium edetate is used widely in topical, oral, and parenteral pharmaceutical formulations; it is used extensively in cosmetic and food products. Disodium edetate and edetate calcium disodium are used in a greater number and variety of pharmaceutical formulations than is edetic acid. Both disodium edetate and edetate calcium disodium are poorly absorbed from the gastrointestinal tract and are associated with few adverse effects when used as excipients in pharmaceutical formulations.
    Disodium edetate, trisodium edetate, and edetic acid readily chelate calcium and can, in large doses, cause calcium depletion (hypocalcemia) if used over an extended period of time, or if administered too rapidly by intravenous infusion. If used in preparations for the mouth, they can also leach calcium from the teeth. However, edetate calcium disodium does not chelate calcium.
    Disodium edetate should be used with caution in patients with renal impairment, tuberculosis, and impaired cardiac function.
    Although disodium edetate is generally considered safe, there have been reports of disodium edetate toxicity in patients receiving chelation therapy.
    Nasal formulations containing benzalkonium chloride and disodium edetate, both known to be local irritants, were shown to produce an inflammatory reaction, and microscopic examination showed an extended infiltration of the mucosa by eosinophils, and pronounced atrophy and disorganization of the epithelium, although these effects were subsequently shown to be reversible.
    The WHO has set an estimated acceptable daily intake for disodium EDTA in foodstuffs of up to 2.5 mg/kg body-weight
    LD50 (mouse, IP): 0.26 g/kg
    LD50 (mouse, IV): 0.056 g/kg
    LD50 (mouse, OP): 2.05 g/kg
    LD50 (rabbit, IV): 0.047 g/kg
    LD50 (rabbit, OP): 2.3 g/kg
    LD50 (rat, OP): 2.0 g/kg
  • Lager Edetate salts are more stable than edetic acid (see also Edetic acid). However, disodium edetate dihydrate loses water of crystallization when heated to 120°C. Aqueous solutions of disodium edetate may be sterilized by autoclaving, and should be stored in an alkali-free container.
    Disodium edetate is hygroscopic and is unstable when exposed to moisture. It should be stored in a well-closed container in a cool, dry place.
  • Inkompatibilitäten Disodium edetate behaves as a weak acid, displacing carbon dioxide from carbonates and reacting with metals to form hydrogen. It is incompatible with strong oxidizing agents, strong bases, metal ions, and metal alloys.
  • Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (inhalations; injections; ophthalmic preparations; oral capsules, solutions, suspensions, syrups, and tablets; rectal topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Ethylenediaminetetraacetic acid disodium salt Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N,N'-1,2-Ethandiylbis(N-(carboxymethyl)glycin,Dinatrium-Salz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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139-33-3, Ethylenediaminetetraacetic acid disodium salt Verwandte Suche:
  • SEQUESTRENE NA2
  • SODIUM (DI) ETHYLENEDIAMINE TETRAACETATE DIHYDRATE
  • VERSENE NA, DIHYDRATE
  • VERSENE DISODIUM
  • WANKLYN'S EDTA
  • TITRAVER(R) HARDNESS REAGENT
  • TITRIPLEX III
  • TITRIPLEX(R) III
  • (ethylenedinitrilo)tetra-aceticacidisodiumsalt
  • cheladrate
  • chelaplexiii
  • chelatoniii
  • complexoniii
  • dinatriumethylendiamintetraacetat
  • disodium(ethylenedinitrilo)tetraacetate
  • disodium(ethylenedinitrilo)tetraaceticacid
  • disodiumdiacidethylenediaminetetraacetate
  • disodiumdihydrogen(ethylenedinitrilo)tetraacetate
  • disodiumedathamil
  • disodiumsaltofedta
  • disodiumsequestrene
  • disodiumtetracemate
  • disodiumversenate
  • disodiumversene
  • dotite2na
  • e.d.t.a.disodique
  • edathamildisodium
  • endratedisodium
  • f1(complexon)
  • Glycine,N,N’-1,2-ethanediylbis[N-(carboxymethyl)]-disodiumsalt
  • kiresutob
  • komplexoniii
  • metaquestb
  • n,n’-1,2-ethanediylbis(n-(carboxymethyl)-glycindisodiumsalt
  • n,n’-1,2-ethanediylbis(n-(carboxymethyl)glycine)disodiumsalt
  • n,n’-1,2-ethanediylbis[n-(carboxymethyl)-glycindisodiumsalt
  • permakleer50crystalsdisodiumsalt
  • permakleerdicrystals
  • selektonb2
  • sequestrenesodium2
  • sodiumversenate
  • tetracematedisodium
  • DISODIUM DIHYDROGEN ETHYLENEDIAMINE TETRAACETATE
  • DISODIUM DIHYDROGEN ETHYLENEDIAMINETETRAACETATE DIHYDRATE
  • DISODIUM DIHYDROGEN ETHYLENEDIAMINETETRA-ACETIC DIHYDRATE
  • EDATHAMIL DISODIUM SALT DIHYDRATE
  • EDETIC ACID, DISODIUM SALT
  • EDETATE DISODIUM
  • EDETATE DISODIUM, DIHYDRATE
  • EDETATE DISODIUM DIHYDROGEN, DIHYDRATE
  • EDETATE DISODIUM SALT DIHYDRATE
  • EDTA-2NA
  • EDTA-2NA DIHYDRATE
  • EDTA DISODIUM
  • EDTA DISODIUM SALT
  • EDTA, DISODIUM SALT, DIHYDRATE, TITRIPLEX(R)
  • EDTA, DISODIUM SALT, DIHYDRATE, TITRIPLEX(R) III
  • EDTA DISODIUM, DIHYDRATE