2-Bromo-4'-hydroxyacetophenone Struktur

2-Brom-1-(4-hydroxyphenyl)ethan-1-on

Bezeichnung:2-Brom-1-(4-hydroxyphenyl)ethan-1-on

CAS-Nr2491-38-5

Englisch Name:2-Bromo-4'-hydroxyacetophenone

CBNumberCB9306895

SummenformelC8H7BrO2

Molgewicht215.04

MOL-Datei2491-38-5.mol

Synonyma

2-Brom-1-(4-hydroxyphenyl)ethan-1-on

2-Brom-1-(4-hydroxyphenyl)ethan-1-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	123-126°C
Siedepunkt	338.7±17.0 °C(Predicted)
Dichte	1.622±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pka	7.69±0.15(Predicted)
Aggregatzustand	White powder
Farbe	White to Light Beige
Sensitive	Lachrymatory
BRN	1865388
Stabilität	Hygroscopic
CAS Datenbank	2491-38-5(CAS DataBase Reference)
EPA chemische Informationen	2-Bromo-4-hydroxyacetophenone (2491-38-5)

Sicherheit

Kennzeichnung gefährlicher	C,Xn
R-Sätze:	22-36
S-Sätze:	26
RIDADR	1760
WGK Germany	1
RTECS-Nr.	AM5982000
Hazard Note	Corrosive/Lachrymatory/Keep Cold
HazardClass	8
PackingGroup	III
HS Code	2914500090

Gefahreninformationscode (GHS)

2-Bromo-4'-hydroxyacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a K_i value of 43 μM and PTP1B with a K_i value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.
Chemische Eigenschaften
Pale Beige Solid
Verwenden
A covalent inhibitor of protein tyrosine phosphatases (PTPs)
synthetische
Also obtained by reaction of pyridinium hydrobromide perbromide with 4-hydroxyacetophenone in THF at r.t. for 3 h.
in vitro
in previous study, the corresponding values of ptp inhibitor i against ptp1b were determined to be ki of 42 μm, kinact of 0.57 min-1, and kinact/ki of 1.4*104 m-1 min-1, respectively. this study also showed that α-bromoacetophenone such as ptp inhibitor i could provide an effective, neutral py mimetic inhibitor of ptps. while perturbation of the electronic properties of the phenyl ring did not significantly improve its potency against ptps, attachment of a proper peptidyl moiety to the para position could improve both the potency and the selectivity substantially. in addition, since the covalent ptp inhibitor complex could be cleaved to regenerate the ptp activity photolytically, ptp inhibitor i might provide a novel class of photolytic switch for controlling cellular signaling processes [1].
Einzelnachweise
[1] arabaci g, yi t, fu h, porter me, beebe kd, pei d. alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-activity relationship. bioorg med chem lett. 2002 nov 4;12(21):3047-50.

2-Bromo-4'-hydroxyacetophenone Upstream-Materialien And Downstream Produkte

2-Brom-1-(4-hydroxyphenyl)ethan-1-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2491-38-5, 2-Bromo-4'-hydroxyacetophenone Verwandte Suche:

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