2-Bromacetophenon

Bezeichnung:2-Bromacetophenon

CAS-Nr70-11-1

Englisch Name:2-Bromoacetophenone

CBNumberCB6305185

SummenformelC8H7BrO

Molgewicht199.04

MOL-Datei70-11-1.mol

Synonyma

2-Bromacetophenon

2-Bromacetophenon physikalisch-chemischer Eigenschaften

Schmelzpunkt	48-51 °C (lit.)
Siedepunkt	135 °C/18 mmHg (lit.)
Dichte	1.476
Brechungsindex	1.5700 (estimate)
Flammpunkt	>230 °F
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Crystals or Powder
Farbe	White to dark green-brown
Wasserlöslichkeit	PRACTICALLY INSOLUBLE
Merck	14,1402
BRN	606474
Stabilität	Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
InChIKey	LIGACIXOYTUXAW-UHFFFAOYSA-N
CAS Datenbank	70-11-1(CAS DataBase Reference)
NIST chemische Informationen	Ethanone, 2-bromo-1-phenyl-(70-11-1)
EPA chemische Informationen	Ethanone, 2-bromo-1-phenyl- (70-11-1)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34-20/21/22
S-Sätze:	26-36/37/39-45
RIDADR	UN 2645 6.1/PG 2
WGK Germany	3
F	8-19
Hazard Note	Corrosive
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29143990

Gefahreninformationscode (GHS)

2-Bromoacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Off white-grey green crystaline powder
Verwenden
2-Bromoacetophenone is a brominated acteophenone derivative. 2-Bromoacetophenone has been shown to completely and irreversibly inactivate human liver aldehyde dehydrogenase (EC 1.2.1.3) isoenzymes E1 and E2. 2-Bromoacetophenone and its derivatives display some inhibitory activity on neutral protein tyrosine.inhibitors
Verwenden
It is used in preparation of crystalline esters from acids. 2-Bromoacetophenone is a complete and irreversible inactivator of human liver aldehyde dehydrogenase isoenzymes E1 and E2.
Definition
ChEBI: An alpha-bromoketone that is acetophenone substituted by a bromo group at position 2.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 5796, 1954 DOI: 10.1021/ja01651a061
Organic Syntheses, Coll. Vol. 2, p. 480, 1943
Synthetic Communications, 22, p. 1923, 1992 DOI: 10.1080/00397919208021322
Allgemeine Beschreibung
A crystalline solid or a liquid with a sharp odor. Toxic by inhalation, ingestion and skin absorption. A severe eye irritant (a lachrymator). Used to make other chemicals.
Air & Water Reaktionen
Reacts slowly with moisture in air to form hydrogen bromide.
Reaktivität anzeigen
2-Bromoacetophenone reacts slowly with metals causing mild corrosion.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Brandgefahr
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
läuterung methode
Crystallise the bromide from EtOH, MeOH or pet ether (b 80-100o). [Tanner J Org Chem 52 2142 1987, Beilstein 7 IV 649.]

2-Bromoacetophenone Upstream-Materialien And Downstream Produkte

2-Bromacetophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

70-11-1, 2-Bromoacetophenone Verwandte Suche:

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