Sodium cloxacillin monohydrate

Bezeichnung:Sodium cloxacillin monohydrate

CAS-Nr7081-44-9

Englisch Name:Sodium cloxacillin monohydrate

CBNumberCB8705413

SummenformelC19H19ClN3NaO6S

Molgewicht475.88

MOL-Datei7081-44-9.mol

Sodium cloxacillin monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	170℃
Siedepunkt	689℃
Flammpunkt	>110°(230°F)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	H2O: soluble50mg/mL
Aggregatzustand	solid
Farbe	White to Orange to Green
Wasserlöslichkeit	Soluble in water
Merck	13,2444
BRN	5403885
CAS Datenbank	7081-44-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-42/43
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	XH8920000
HS Code	29411099

Gefahreninformationscode (GHS)

Sodium cloxacillin monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Cloxacillin was synthesized by Beecham Research Laboratories in 1962 starting with 6- aminopenicillanic acid. It was the first semisynthetic penicillin with a halogen atom in the side chain to be used clinically. It shows 5- to 20-fold stronger activity than methicillin and is twice as active as oxacillin against Staphylococcus aureus, including benzylpenicillin-resistant strains. Cloxacillin is highly stable against penicillinase and well absorbed by oral administration. It has been widely used, by oral and intramuscular administration, to treat internal, surgical, gynecological, and other infections caused by both benzylpenicillin-sensitive and benzylpenicillin-resistant bacteria.
Chemische Eigenschaften
White or almost white, hygroscopic, crystalline powder.
Verwenden
Targets primarily Gram-positive bacteria, especially -lactamase producing Staphylococci
Verwenden
Penicillin antibacterial.
Definition
ChEBI: Cloxacillin sodium monohydrate is an organic sodium salt and a hydrate. It contains a cloxacillin sodium.
Trademarks
Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).
Kontakt-Allergie
Cloxacillin is a semisynthetic penicillin close to oxacillin. It induced contact dermatitis in a pharmaceutical factory worker with positive reactions to ampicillin, but not to penicillin. In cutaneous drug reactions such as acute generalized exanthematous pustulosis due to amoxicillin, cross-reactivity is frequent to cloxacillin (personal observations).
Clinical Use
The chlorine atom ortho to the position of attachment of thephenyl ring to the isoxazole ring enhances the activity ofcloxacillin sodium, [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodium monohydrate (Tegopen), over that ofoxacillin, not by increasing its intrinsic antibacterial activitybut by enhancing its oral absorption, leading to higher plasmalevels. In almost all other respects, it resembles oxacillin.
Sicherheitsprofil
Moderately toxic by intraperitoneal, intramuscular, subcutaneous, and intravenous routes. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl-, NOx, Na2O, and SOx.
Veterinary Drugs and Treatments
Cloxacillin is used via intramammary infusion in dry and lactating dairy cattle.

Sodium cloxacillin monohydrate Upstream-Materialien And Downstream Produkte

Sodium cloxacillin monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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