Cloxacillinnatrium

Bezeichnung:Cloxacillinnatrium

CAS-Nr642-78-4

Englisch Name:Cloxacillin-13C4 SodiuM Salt

CBNumberCB5705412

SummenformelC19H19ClN3NaO5S

Molgewicht459.88

MOL-Datei642-78-4.mol

Synonyma

Cloxacillinnatrium

Cloxacillinnatrium physikalisch-chemischer Eigenschaften

Schmelzpunkt	170°C
storage temp.	2-8°C
Löslichkeit	H₂O: 50 mg/mL, clear, colorless
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water
BCS Class	3
Stabilität	Stable. Incompatible with strong oxidizing agents. Refrigerate.
CAS Datenbank	642-78-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-42/43
S-Sätze:	26-36-22
WGK Germany	2
RTECS-Nr.	XH8920000

Gefahreninformationscode (GHS)

Cloxacillin-13C4 SodiuM Salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Beschreibung
Cloxacillin is a β-lactam antibiotic and a derivative of oxacillin . It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 μg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 μg/ml for all). Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC₅₀s = 0.04, 0.12, 0.21, and 2.5 μg/ml, respectively). It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (K_is = 15, 0.27, and 0.027 μM, respectively). Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.
Chemische Eigenschaften
White Crystalline Powder
Originator
Orbenin,Beecham,UK,1962
Verwenden
Ropivacaine (R675000) metabolite.
Verwenden
Labelled S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.
Verwenden
Cloxacillin-13C4 SodiuM Salt is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.
Verwenden
Cloxacillin-13C4 SodiuM Salt, an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lac tamase due to its inhibitory effects on beta-lactamase binding.
Definition
ChEBI: Cloxacillin sodium is an organic sodium salt. It contains a cloxacillin(1-).
Manufacturing Process
The reaction between 6-aminopenicillanic acid (6.5 g) and 3-o-chlorophenyl-5- methylisoxazole4-carbonyl chloride (7.66 g) gave the sodium salt of 3-ochlorophenyl-5-methyl-4-isoxazolylpenicillin (9.98 g) as a pale yellow solid. Colorimetric assay with hydroxylamine against a benzylpenicillin standard indicated a purity of 68%.
The 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid, from which the acid chloride was prepared, was obtained by hydrolysis of the ester product of the reaction between o-chlorobenzohydroxamic chloride and ethyl acetoacetate in methanolic sodium methoxide. Reaction with thionyl chloride gave the starting material.
Trademarks
Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).
Therapeutic Function
Antibacterial
läuterung methode
Purify cloxacillin sodium salt by dissolving it in isoPrOH containing 20% of H2O, and diluting with isoPrOH to a water content of 5% and chilling. Recrystallise it again in this manner. The sodium salt is collected and dried at 40o in air to give the colourless monohydrate. It is soluble in H2O (5%), MeOH, EtOH, pyridine and ethylene glycol. [Doyle et al. J Chem Soc 5838 1963, Naylor et al. Nature 195 1264 1962.] ( ) -Cocaine {ecogonine methyl ester benzoate, 2 -carbomethoxy-3--benzoxytropane, methyl 1R -(exo,exo)]-3-(benzoyloxy)-2-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate}

Cloxacillin-13C4 SodiuM Salt Upstream-Materialien And Downstream Produkte

Cloxacillinnatrium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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