Propidium iodide Struktur

3,8-Diamino-5-(3-(diethylmethylam-monio)-propyl)-6-phenylphenanthri-diniumdiiodid

Bezeichnung:3,8-Diamino-5-(3-(diethylmethylam-monio)-propyl)-6-phenylphenanthri-diniumdiiodid

CAS-Nr25535-16-4

Englisch Name:Propidium iodide

CBNumberCB8703712

SummenformelC27H34IN4+

Molgewicht541.5

MOL-Datei25535-16-4.mol

Synonyma

3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridiniumdiiodid

3,8-Diamino-5-(3-(diethylmethylam-monio)-propyl)-6-phenylphenanthri-diniumdiiodid

3,8-Diamino-5-(3-(diethylmethylam-monio)-propyl)-6-phenylphenanthri-diniumdiiodid physikalisch-chemischer Eigenschaften

Schmelzpunkt	220-225 °C (dec.) (lit.)
Dichte	1.5072 (estimate)
storage temp.	2-8°C
Löslichkeit	Difficult to mix.
Aggregatzustand	Flaky Powder
Farbe	Dark red
Wasserlöslichkeit	Soluble in water at 1mg/ml
Sensitive	Light Sensitive & Hygroscopic
maximale Wellenlänge (λmax)	493 nm, 535 nm
BRN	3843838
Biologische Anwendungen	Detecting nucleic acids,cancer cells,spores,activity of hydrolase,microorganisms; apoptosis assay; measuring beta-amyloid in Alzheimer’s disease (AD); treating diseases associated with androgens,cancer
Major Application	Electroluminescent displays; photoresists
CAS Datenbank	25535-16-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-68-67-48/20/22-40-36/38-22-20-63
S-Sätze:	26-36-22-36/37
WGK Germany	3
RTECS-Nr.	SF7949600
F	3-8-10-23
HS Code	29339900

Gefahreninformationscode (GHS)

Propidium iodide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Beschreibung
Propidium iodide (PI) is membrane impermeant and generally excluded from viable cells. However, it can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques. It binds to DNA and RNA by intercalating between the bases. PI is excited at 488-535 nm with an emission maximum of 617 nm. This probe is suitable for fluorescence microscopy and flow cytometry.
Chemische Eigenschaften
Dark Red Solid
Verwenden
Used as fluorescent stain for nucleic acids,and used in flow cytometry to evaluate cell viability
Verwenden
Antibacterial;Detergent
Verwenden
1 mg/mL in water
Verwenden
Propidium iodide is the most common red-fluorescent nuclear stain. It can also be excited using excitation filters appropriate for green-fluorescent dyes.
Verwenden
Propidium Iodide is a phenanthridine compound, a class of compounds with reported activity against several species of trypanosomes. Propidium iodide may be used in flow cytometry to evaluate cell viab ility when used with other dyes that stain viable cells or cells that are early in the apoptosis process.
Definition
ChEBI: Propidium iodide is an organic iodide salt. It contains a propidium.
Allgemeine Beschreibung
Extinction coefficient(493 nm): 5900 M ^-1cm^-1;(287 nm): 55,700 M ^-1cm^-1;
Biochem/physiol Actions
Primary TargetMembrane impermeable DNA intercalator
Lager
+4°C
läuterung methode
It crystallises as red crystals from H2O containing a little KI. It fluoresces strongly with nucleic acids. [Watkins J Chem Soc 3064 1952, Beilstein 22 III/IV 5519.] TOXIC.

3,8-Diamino-5-(3-(diethylmethylam-monio)-propyl)-6-phenylphenanthri-diniumdiiodid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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