Mebendazol Produkt Beschreibung

Mebendazole Struktur
31431-39-7
  • CAS-Nr.31431-39-7
  • Bezeichnung:Mebendazol
  • Englisch Name:Mebendazole
  • Synonyma:Mebendazol
    mbdz;Mebex;telmin;r17635;vermox;lomper;noverme;verpanyl;vermirax;bantenol
  • CBNumber:CB8700094
  • Summenformel:C16H13N3O3
  • Molgewicht:295.29
  • MOL-Datei:31431-39-7.mol
Mebendazol physikalisch-chemischer Eigenschaften
Sicherheit
  • Kennzeichnung gefährlicher :Xn
  • R-Sätze: :22
  • S-Sätze: :36
  • RIDADR  :UN 2811
  • WGK Germany  :3
  • RTECS-Nr. :EY8600000
  • HS Code  :29339900
  • Giftige Stoffe Daten :31431-39-7(Hazardous Substances Data)
  • Toxizität :LD50 orally: >80 mg/kg in sheep; >40 mg/kg in mice, rats and chickens (Van Gelder)

Mebendazole Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
  • S-Sätze Betriebsanweisung: S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Chemische Eigenschaften White Amorphous Powder
  • Verwenden Anthelmintic (Nematodes)
  • Verwenden For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.
  • Definition ChEBI: A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
  • Indications Unlike thiabendazole, mebendazole (Vermox) does not inhibit fumarate reductase.While mebendazole binds to both mammalian and nematode tubulin, it exhibits a differential affinity for the latter, possibly explaining the selective action of the drug. The selective binding to nematode tubulin may inhibit glucose absorption, leading to glycogen consumption and ATP depletion.
  • Trademarks Vermox (McNeil).
  • Allgemeine Beschreibung White to slightly yellow powder. Pleasant taste. Practically water insoluble.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen Mebendazole is a carbamate ester-amine. Amines behave as chemical bases. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
  • Brandgefahr Flash point data for Mebendazole are not available; however, Mebendazole is probably combustible.
  • Pharmazeutische Anwendungen A benzimidazole carbamic acid methyl ester available for oral administration. It is insoluble in water and stable at room temperature.
  • Mechanism of action Mebendazole is given orally; it is poorly soluble, and very little is absorbed from the intestinal tract. About 5 to 10%, principally the decarboxylated derivatives, is recovered in the urine; most of the orally administered drug is found in the feces within 24 hours.
  • Pharmakokinetik Oral absorption is poor. Plasma concentrations achieved after oral administration of 100 mg every 12 h for three consecutive days do not exceed 0.03 mg/L. All metabolites are inactive. Most of the dose, as unchanged drug or a primary metabolite, is retained in the intestinal tract and passed in the feces, with the remainder, approximately 2% of the dose, excreted in the urine.
  • Clinical Use Methyl 5-benzoyl-2-benzimidazolecarbamate (Vermox) isa broad-spectrum anthelmintic that is effective against variousnematode infestations, including whipworm, pinworm,roundworm, and hookworm. Mebendazole irreversiblyblocks glucose uptake in susceptible helminths, thereby depletingglycogen stored in the parasite. It apparently does notaffect glucose metabolism in the host. It also inhibits cell divisionin nematodes.
    Mebendazole is poorly absorbed by the oral route.Adverse reactions are uncommon and usually consist of abdominaldiscomfort. It is teratogenic in laboratory animalsand, therefore, should not be given during pregnancy.
  • Clinical Use Mebendazole is used primarily for the treatment of A. lumbricoides, T. trichiura, E. vermicularis, and hookworm infections, in which it produces high cure rates. It is an alternative agent for the treatment of trichinosis and visceral larva migrans. Owing to its broad-spectrum anthelmintic effect, mixed infections (ascariasis, hookworm infestation, or enterobiasis in association with trichuriasis) frequently respond to therapy. High doses have been used to treat hydatid disease, but albendazole is now thought to be superior.
  • Clinical Use Intestinal nematode infections
    Trichinosis (larval stage)
  • Nebenwirkungen Diarrhea and gastrointestinal discomfort may occur, but adverse reactions are generally mild. Woman of childbearing age should be informed of a potential risk to the fetus if treated during pregnancy, particularly during the first trimester.
  • Nebenwirkungen Abdominal discomfort and diarrhea may occur when the worm load is heavy. Its use is contraindicated during pregnancy.
  • Sicherheitsprofil Moderately toxic by ingestion and intraperitoneal routes. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES.
Mebendazole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Mebendazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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31431-39-7, Mebendazole Verwandte Suche:
  • r17635
  • telmin
  • vermicidin
  • vermirax
  • vermox
  • verpanyl
  • CHEMBRDG-BB 5250893
  • METHYL N-(5-BENZOYL-1H-BENZIMIDAZOL-2-YL)CARBAMATE
  • METHYL 5-BENZOYL BENZIMIDAZOLE-2-CARBAMATE
  • METHYL 5-BENZOYL-2-BENZIMIDAZOLE-CARBAMATE
  • MEBENDAZOL
  • MEBENDAZOLE
  • LABOTEST-BB LT00134664
  • (5-Benzoyl-1H-benzimidazol-2-yl)carbamicacidmethylester
  • (5-benzoyl-1h-benzimidazol-2-yl)-carbamicacidmethylester
  • (5-benzoyl-1h-benzimidazol-2-yl)-carbamicacimethylester
  • 5-benzoyl-2-benzimidazolecarbamicacimethylester
  • bantenol
  • besantin
  • lomper
  • mbdz
  • mebenvet
  • methyl5-benzoyl-2-benzimidazolylcarbamate
  • methyln-(5-benzoyl-2-benzimidazolyl)carbamate
  • n-(5-benzoylbenzimidazol-2-yl)-carbamicacimethylester
  • n-(benzoyl-5,benzimidazolyl)-2,carbamatedemethyle
  • n-2(5-benzoyl-benzimidazole)carbamatedemethyle
  • noverme
  • ovitelmin
  • pantelmin
  • 5-BENZOYL-2-BENZIMIDAZOLECARBAMIC ACID METHYL ESTER
  • 5-benzoyl-2-benzimidazolylcarbamic acid methyl ester
  • AKOS NCG1-0041
  • methyl 5-benzoylbenzimidazol-2-ylcarbamate
  • MEBENDAZOLE USP
  • Mebendazole BP98 and USP24
  • MebendazoleMebendazoleUsp
  • Mebex
  • N-(6-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester
  • Mebendazolum
  • Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester
  • bantenol besantin
  • 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester, Mebendazol, Methyl N-(5-benzoyl-1H-benzimidazol-2-yl)carbamate
  • Mebendazole POLY-C
  • Equivurm Plus
  • Methyl [(5-benzoyl-3H-benzoimidazol-2-yl)amino]formate
  • N-(5-Benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl
  • Methyl benzoyl benzimidazole carbamate
  • methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate(SALTDATA: FREE)
  • Mebendazole (200 mg)
  • 5-Benzoyl-2-benziMidazolecarbaMic Acid-d8 Methyl Ester
  • Bantenol-d8
  • Mebenvet-d8
  • Mebex-d8
  • N-(6-Benzoyl-1H-benziMidazol-2-yl)carbaMic Acid-d8 Methyl Ester
  • NoverMe-d8
  • OvitelMin-d8
  • PantelMin-d8