Methyl-4-acetamido-2-ethoxybenzoat

Bezeichnung:Methyl-4-acetamido-2-ethoxybenzoat

CAS-Nr59-06-3

Englisch Name:Ethopabate

CBNumberCB1307306

SummenformelC12H15NO4

Molgewicht237.25

MOL-Datei59-06-3.mol

Synonyma

Methyl-4-acetamido-2-ethoxybenzoat

Methyl-4-acetamido-2-ethoxybenzoat physikalisch-chemischer Eigenschaften

Schmelzpunkt	148-151 °C
Siedepunkt	426.1±35.0 °C(Predicted)
Dichte	1.180±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: 50 mg/mL (210.75 mM)
Aggregatzustand	A solid
pka	14.12±0.70(Predicted)
Farbe	White to off-white
Merck	13,3781
InChI	InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14)
InChIKey	GOVWOKSKFSBNGD-UHFFFAOYSA-N
SMILES	C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC
CAS Datenbank	59-06-3(CAS DataBase Reference)
EPA chemische Informationen	Ethopabate (59-06-3)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3
HS Code	2924296000

Gefahreninformationscode (GHS)

Ethopabate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Beschreibung
Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.
Verwenden
antidepressant
Definition
ChEBI: Ethopabate is an amidobenzoic acid.
Clinical Use
Ethopabate is only a narrow anticoccidial spectrum drug against Eimeria acervulina. It has no or only slight activity against E. maxima, E. necatrix, E. tenella or E. brunetti. Today, ethopabate is applied only in combination with amprolium and sulfonamide.
Molecular Interactions
Ethopabate is a 2-substituted PABA derivative (=4-acetamido-2-ethoxybenzoic acid methylester) and functions as a prodrug. Its activity becomes potentiated by pyrimethamine and antagonised by the simultaneous administration of PABA. Thus, the mode of action of ethopabate is similar to that of sulfonamides or sulfones.

Ethopabate Upstream-Materialien And Downstream Produkte

Methyl-4-acetamido-2-ethoxybenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

59-06-3, Ethopabate Verwandte Suche:

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