(+)-2-Aminopropan-1-ol

Bezeichnung:(+)-2-Aminopropan-1-ol

CAS-Nr2749-11-3

Englisch Name:L-Alaninol

CBNumberCB8693194

SummenformelC3H9NO

Molgewicht75.11

MOL-Datei2749-11-3.mol

Synonyma

(+)-2-Aminopropan-1-ol

(+)-2-Aminopropan-1-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	-2°C
Siedepunkt	72-73 °C11 mm Hg(lit.)
alpha	21.8 º (c=2,ethanol)
Dichte	0.965 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.450
Flammpunkt	145 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Wasserlöslichkeit	Completely miscible in water
Löslichkeit	Chloroform, Methanol (Slightly)
Aggregatzustand	Oily Liquid
pka	12.88±0.10(Predicted)
Wichte	0.96
Farbe	Clear colorless to yellow
Optische Aktivität	[α]20/D +18°, neat
Sensitive	Hygroscopic
BRN	1718865
CAS Datenbank	2749-11-3(CAS DataBase Reference)
NIST chemische Informationen	1-Propanol, 2-amino-, (S)-(2749-11-3)

Sicherheit

Kennzeichnung gefährlicher	C,Xi
R-Sätze:	34-36/37/38
S-Sätze:	26-36/37/39-45-36
RIDADR	UN 2735 8/PG 2
WGK Germany	3
F	10-23
HazardClass	8
PackingGroup	III
HS Code	29221990

Gefahreninformationscode (GHS)

L-Alaninol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Colorless liquid
Verwenden
(S)-(+)-2-Amino-1-propanol (L-Alaninol) may be used in the preparation of unsymmetrical tridentate Schiff base ligands via condensation with carbonyl compounds. It may also be used as a chiral auxillary for the preparation of tert-butyl 4-N-[(2-hydroxy-1-(S)-methyl)ethylamino]-2-methylene-4-(S)-phenyl-butyrate.
Verwenden
S-(+)-2-Amino-1-propanol is an aliphatic amino alcohol shown to induce an antiproliferative effect in B16 melanoma cells. S-(+)-2-Amino-1-propanol is used in the preparation of oxazolines which are of ten used as ligands in homogeneous catalysis.
Definition
ChEBI: An amino alcohol that is L-alanine in which the carboxy group has been reduced to the corresponding alcohol.
Biochem/physiol Actions
Pseudomonas sp. strain KIE171 was able to grow with L-alaninol [S-(+)-2-amino-1-propanol] as the sole carbon source[1]. W?sch et al. found that mutant KIE171-BI transformed isopropylamine to L-alaninol, mutant KIE171-BII failed to do so.
Synthese
Simply produce L-alaninol in high yield and good reproducibility by directly reducing an inorganic acid salt of an L-alanine ester with NaBH4. 3.0 mol of NaBH 4 was added and dissolved in 560 ml of cold water, and L-alanine ethyl ester hydrochloride 1. A solution of 0 mol dissolved in 560 ml of ethanol was added. The mixture was added dropwise at 20 ° C. over 5 hours and further aged at 20 to 28 ° C. to complete the reaction. After the reaction, excess NaBH 4 was decomposed with acetone, 1000 ml of ethyl acetate was introduced, and the precipitated inorganic substance was separated by filtration. The lower aqueous layer portion of the filtrate was extracted with 600 ml of ethyl acetate; the ethyl acetate layer was distilled under reduced pressure to remove the solvent and then vacuum distilled to yield L-alaninol.
läuterung methode
Purify it as for S-2-amino-3-methylbutan-1-ol below. [Beilstein 4 IV 1615.]
Einzelnachweise
[1] Susana I de Azevedo W?sch. “Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates.”Applied and Environmental Microbiology (2002): 68.

L-Alaninol Upstream-Materialien And Downstream Produkte

(+)-2-Aminopropan-1-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2749-11-3, L-Alaninol Verwandte Suche:

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