Ergometrin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

  H311：Giftig bei Hautkontakt.

  H331：Giftig bei Einatmen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P311：GIFTINFORMATIONSZENTRUM/Arzt anrufen.

  P312：Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P321：Besondere Behandlung

  P322：Gezielte Maßnahmen

  P330：Mund ausspülen.

  P361：Alle kontaminierten Kleidungsstücke sofort ausziehen.

  P363：Kontaminierte Kleidung vor erneutem Tragen waschen.

  P403+P233：An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.

  P405：Unter Verschluss aufbewahren.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

ERGONOVINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

• Chemische Eigenschaften

  solid

• Originator

  Ergotrate,Lilly

• Verwenden

  Ergonovine is a water-soluble lysergic acidderivative that occurs in ergot. It is used as anoxytocic agent. Its maleate derivative is usedin the treatment of postpartum hemorrhage.

• Verwenden

  Oxytocic.

• Definition

  ChEBI: A monocarboxylic acid amide that is lysergamide in which one of the hydrogens attached to the amide nitrogen is substituted by a 1-hydroxypropan-2-yl group (S-configuration). An ergot alkaloid that has a particularly powerful action on th uterus, its maleate (and formerly tartrate) salt is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vesse s in the uterine wall are compressed and blood flow reduced.

• Manufacturing Process

  A solution of the mixed anhydride of lysergic acid and trifluoroacetic acid is prepared from 530 mg of d-lysergic acid and 930 mg of trifluoroacetic anhydride in 30 ml of acetonitrile at -20°C. The mixture is allowed to stand at -20°C for about 1.5 hours during which time the suspended material dissolves, and the d-lyserginic acid is converted to the mixed anhydride of liserginic and trifluoroacetic acids. The mixed anhydride can be separated as an oil by evaporating the solvent in vacuo at a temperature about 0°C. The solution containing the mixed anhydride is added to a solution of 300 mg of L- (+)-2-aminopropan-1-ol, and 640 mg of triethylamine in 15 ml of acetonitrile, the triethylamine being employed to displace any L-(+)-2-aminopropan-1-ol from adducts with acid components of the reaction mixture. After 15 minutes of standing at room temperature, the reaction mixture is filtered, and the crystalline material thus obtained is washed with acetonitrile and dried in air. This material is substantially pure d-lysergic acid. The filtrate which contains the desired reaction product is evaporated to dryness in vacuo. The residue is treated with chloroform and water. The chloroform layer is separated, and the aqueous layer is extracted with 4x50 ml portions of chloroform. The combined chloroform extracts washed 4x50 ml portions of cold water in order to remove the residual amounts of amine salts, dried over sodium sulfate and the chloroform is evaporated yielding a crystalline material, which separates when the volume of residual solution is decreased to about 2 ml. The solution is chilled, thereby, causing further crystalline material to separate from solution. The crystalline material is substantially pure ergonovine. The crystalline ergonovine is removed from the solution by filtration, is washed with cold chloroform and dried. MP: 155°-156°C. Paper chromatography shows that this compound is identical with authentic ergonovine produced from crude ergot.
  The mother liquors and chloroform washes from the above crystallization of ergonovine are combined, and the solvents are evaporated in vacuo. The residue containing ergonovinine (the "iso" form of ergonovine) is dissolved in 2 ml of ethyl acetate. From this solution crystalline ergonovinine precipitates almost immediately. The crystals are separated by filtration and dried. A sample melts at about 188-190°C. The ergonovinine can be isomerized to ergonovine with alkali for example by employing the method of Stoll and Hofmann, Helvetica Chimica Acta 26, 944 (1943).
  The ethyl acetate mother liquor from the preceding isolation of ergonovinine is evaporated to dryness in vacuo and the residue (the mixture of 1- aminopropan-2-ol esters of d-lysergic acid and of d-iso-lysergic acid) is dissolved in 2 ml of ethanol. 0.4 ml of 4 N potassium hydroxide solution in 50% aqueous ethanol are then added, and the resulting mixture is allowed to stand at room temperature in the dark for about two hours. This treatment of the aminopropanol esters of d-lysergic acid and d-isolysergic acid with base rearranges them to the propanol amides of d-lysergic acid and d-iso-lysergic acid, which are ergonovine and ergonovinine, respectively. Solid carbon dioxide is added to the reaction mixture in order to neutralize the potassium hydroxide. The solvents are then removed in vacuo and the residue of
  ergonovine and ergonovinine is separated into its components by a chromatogrophy on the basic alumina. Two blue fluorescing zone appear on the alumina column and could light isolate. The mixture (3:1) of benzene and chloroform is used as eluent.

• Trademarks

  Ergotrate Maleate (Lilly).

• Therapeutic Function

  Oxytocic, Abortifacient

• Hazard

  Extremely toxic; vaso-constrictor; central nervous system stimulant; adrenergic blocking compound.

• Health Hazard

  The toxicity of ergonovine is low to moderate.The toxic symptoms include excitability,respiratory depression, cyanosis, and convulsions.The intravenous LD50 value in mice is144 mg/kg.

ERGONOVINE Upstream-Materialien And Downstream Produkte

60-79-7, ERGONOVINE Verwandte Suche: