alpha, alpha-Diphenyl-1-piperidinbutanol

Difenidol Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Vontrol,SKF,US,1967

• Verwenden

  Anti-emetic.

• Definition

  ChEBI: A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4.

• Manufacturing Process

  2.6 grams magnesium, activated by means of iodine, is introduced into 20 cc of absolute ether and is caused to react with 0.6 cc of ethyl
  omide. While warming gently, 16.2 grams (0.1 mol) of N-[1-chloropropyl-(3)]-piperidine in 40 cc of absolute ether are added and, after adding a further 0.5 cc of ethyl
  omide, 14.5 grams (0.08 mol) of benzophenone in 50 cc of anhydrous ether are added in portions. The magnesium is used up fairly quickly and, after 10 hours, only traces are left. In working up, both with hydrochloric acid and with ammonium chloride, the hydrochloride of diphenyl-3-piperidinopropyl carbinol is precipitated as a dense precipitate. It is purified by recrystallization from chloroform-ethyl acetate. MP 212-214°C.

• Therapeutic Function

  Antinauseant

• Handelsname

  Vontrol (Smith Kline & French), Cephadol (Nippon Shinyaku).

Difenidol Upstream-Materialien And Downstream Produkte

alpha, alpha-Diphenyl-1-piperidinbutanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(34)Suppliers

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