N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin

Bezeichnung:N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin

CAS-Nr475-31-0

Englisch Name:Glycocholic acid

CBNumberCB8378590

SummenformelC26H43NO6

Molgewicht465.63

MOL-Datei475-31-0.mol

Synonyma

N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin

N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin physikalisch-chemischer Eigenschaften

Schmelzpunkt	128°C
Siedepunkt	568.76°C (rough estimate)
Dichte	1.1336 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	Refrigerator
Löslichkeit	methanol: 0.1 g/mL, clear, colorless
Aggregatzustand	Solid
pka	4.4(at 25℃)
Farbe	White to Off-White
Wasserlöslichkeit	329.9mg/L(20 ºC)
Merck	13,4507
Stabilität	Hygroscopic
InChIKey	RFDAIACWWDREDC-NSPZZGDONA-N
LogP	1.650
CAS Datenbank	475-31-0(CAS DataBase Reference)
NIST chemische Informationen	Glycocholic acid(475-31-0)

Sicherheit

Kennzeichnung gefährlicher	N
R-Sätze:	51/53
S-Sätze:	61
RIDADR	UN 3077 9/PG 3
WGK Germany	3

Gefahreninformationscode (GHS)

Glycocholic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
N-Cholylglycine. Bile salt, conjugate of cholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.
Beschreibung
Glycocholic acid is a glycine-conjugated form of the primary bile acid cholic acid and has roles in the emulsification of fats. It reduces expression of the gene encoding the farnesoid X receptor (FXR) and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells when used at a concentration of 1.6 μmol/ml. Glycocholic acid (250 μM) increases the intracellular accumulation and cytotoxicity of epirubicin in Caco-2 cells, as well as decreases expression of the genes encoding multidrug resistance protein 1 (MDR1), MDR-associated protein 1 (MRP1), and MRP2 when used alone or in combination with epirubicin. It increases absorption of epirubicin into everted sacs of rat ileum and jejunum when used at a concentration of 250 μM. The bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases. Serum levels of glycocholic acid are elevated in patients with hepatocellular carcinoma compared with healthy individuals.
Chemische Eigenschaften
Off-White Solid
Verwenden
Labelled Glycocholic Acid. The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt.
Definition
ChEBI: A bile acid glycine conjugate having cholic acid as the bile acid component.
läuterung methode
Glycocholic acid crystallises from hot water as the sesquihydrate. Dry it at 110o in vacuo. An analytical sample is prepared by suspending the acid (4g) in H2O (400mL) at ~20o, heating to boiling with slow stirring, filtering hot and allowing to cool to ~20o. The acid is filtered off, washed with H2O, dried in air, recrystallised from 5% aqueous EtOH, washed well and dried over P2O5 in a moderate vacuum to constant weight. Recrystallisation from EtOH/EtOAc, and drying, gave the anhydrous acid. [Cortese & Bauman J Am Chem Soc 57 1393 1935, Bergstrom & Norman Acta Chem Scand 7 1126 1953, Beilstein 10 IV 2077.]

Glycocholic acid Upstream-Materialien And Downstream Produkte

N-(3-α,7-α,12-α-Trihydroxycholan-24-oyl)glycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

475-31-0, Glycocholic acid Verwandte Suche:

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