Fludarabin Produkt Beschreibung

Fludarabine Struktur
21679-14-1
  • CAS-Nr.21679-14-1
  • Bezeichnung:Fludarabin
  • Englisch Name:Fludarabine
  • Synonyma:Fludarabin
    f-ara-a;Fludara;2-F-ARAA;NSC 118218;NSC-312887;NSC-328002;ludarabine;21697-14-1;Fludarbine;NSC 118218H
  • CBNumber:CB8188247
  • Summenformel:C10H12FN5O4
  • Molgewicht:285.23
  • MOL-Datei:21679-14-1.mol
Fludarabin physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :265-268°C
  • alpha  :D25 +17 ±2.5° (c = 0.1 in ethanol)
  • storage temp.  :2-8°C
  • Löslichkeit :DMF: 20 mg/mL, clear, faintly yellow
  • Aggregatzustand :Powder
  • Farbe :White to Pale Yellow
  • Wasserlöslichkeit :Soluble in DMF, DMSO, methanol or ethanol. Sparingly soluble in water
  • Merck  :13,4152
  • BRN  :1225932
  • CAS Datenbank :21679-14-1(CAS DataBase Reference)
Sicherheit

Fludarabine Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
    R39:Ernste Gefahr irreversiblen Schadens.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  • Chemische Eigenschaften White Solid
  • Verwenden Used as an antineoplastic
  • Verwenden A STAT-1 activation inhibitor and a DNA synthesis inhibitor.?
  • Verwenden phosphate as antineoplastic;inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase
  • Verwenden Irreversible muscarinic agonist
  • Verwenden DNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription
  • Allgemeine Beschreibung The drug is available as the phosphate salt in a 50-mg vialfor IV use. Fludarabine is used to treat chronic lymphocyticleukemia and non-Hodgkin’s lymphoma. The mechanism ofaction involves the triphosphate metabolite and its inhibitionof DNA chain elongation. The 2-fluoro group on the adeninering renders fludarabine resistant to breakdown byadenosine deaminase. The drug is rapidly dephosphorylatedto 2-fluoro-ara-adenosine (F-ara-A) after administration. Fara-A is taken into the cell and subsequently re-phosphorylatedto yield the triphosphate (F-ara-ATP), the active drugspecies. Resistance can occur via decreased expression ofthe activating enzymes and decreased drug transport.Fludarabine is orally bioavailable and is distributed throughoutthe body reaching high levels in liver, kidney, andspleen. The drug is metabolized to F-ara-A, which enterscells via the nucleoside transport system and is rephosphorylatedby deoxycytidine kinase to fludarabine monophosphateand finally fludarabine triphosphate, the activespecies. About 25% of F-ara-A is excreted unchanged inurine. Drug interactions include an increased incidence offatal pulmonary toxicity when fludarabine is used in combinationwith pentostatin. Additionally, fludarabine may potentiate the effects of several other anticancer drugs includingcytarabine, cyclophosphamide, and cisplatin.Toxicities include myelosuppression, immunosuppression,fever, nausea, and vomiting.
  • Biologische Aktivität Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo .
Fludarabine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fludarabin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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21679-14-1, Fludarabine Verwandte Suche:
  • 2-Fluoroadeninearabinoside
  • 9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin
  • 9-beta-d-arabinofuranosyl-2-fluoro-adenin
  • f-ara-a
  • 6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE
  • 9--D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
  • NSC 118218
  • NSC 118218H
  • 9-β-D-Arabinofuranosyl-2-fluoroadenine, F-ara-A, Fludarabine des-phosphate
  • 2-F-ara-Amp
  • 9-β-D-Arabinohanosyl-2-fluo-roadenine
  • Fludara
  • 9-bata-d-arabinofuranosyl-2-fluoroadenine
  • 9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE
  • NSC-312887
  • NSC-328002
  • (2R,3S,4S,5R)-2-(6-Amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • LUDARABINE BASE
  • Fludarabine(Fludara)
  • (2R,3S,4S,5R)-2-(6-aMino-2-fluoro-9H-purin-9-yl)-5-(hydroxyMethyl)-tetrahydrofuran-3,4-diol
  • {[(2R,3S,4S,5R)-5-(6-aMino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]Methoxy}phosphonic acid
  • Fludarabine API
  • Fludarabine (IMpurity E)
  • Fludarabinum
  • Fludarabine, >=99%
  • 2-Fluoro-arabinoadenosine
  • ludarabine
  • 9-b-D-Arabinofuranosyl-2-fluoroadenine
  • 9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE
  • 9-D-ARUBINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE
  • 2-F-ARAA
  • 2-FLUORO-9-ARABINOADENINE
  • 2-fluoroadenine-9-bata-d-arabinofuranoside
  • 2-FLUOROADENINE 9-BETA-D-ARABINOFURANOSIDE
  • FLUDARUBINE
  • FLUDARABINE
  • FLUDARABINE BASE
  • FLUDARABINE DES-PHOSPHATE
  • 2-FLUOROADENINE 9-B-D-ARABINOFURANOSIDE
  • 2-FLUOROADENINE-9-BETA-D-ARABINOFURANO-&
  • Fludarabine&Int.
  • ARABINOFURANOSYL-2-FLUOROADENINE
  • 9-b-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine, 2-F-araA
  • 9H-Purin-6-amine, 9-b-D-arabinofuranosyl-2-fluoro-
  • 2-fluoroadenine-9-β-d-arabinofuranoside
  • 9-β-d-arabinofuranosyl-2-fluoroadenine
  • 2-Fluoro-9-arabinoadenine (Fludarabine)
  • Fludarabine(TABINS)
  • FLUDARABINE [2-FLUOROADENINE-9-BETA-D-ARABINOFURANOSIDE]
  • 2-FLUORO-9-β-D-ARABINOFURANOSYLADENINE (FLUDARABINE: F-ARA-A)
  • FLUDARABINE BASE :9-D-ARUBINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE
  • 2-Fluoro-9--D-arabinofuranosyladenine
  • 21697-14-1
  • 2-Fluoro-9-beta-D-arabinofuranosyladenine
  • 2-Fluoro-arabinoadenosine, Fludarabine
  • Fludarbine
  • Fludarabine (NSC-118218)
  • (2R,3S,4R,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol